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Literature DB >> 26440701

Beyond Genomics: Multidimensional Analysis of Cancer Therapy Resistance.

Abstract

Cancer resistance to therapy occurs through a selection process generally thought to be driven by mutations. In a recent study, Hugo et al. use multidimensional analysis of the dynamic genetic, transcriptional, epigenetic, and immune landscape alterations in baseline and MAPK inhibitor-resistant melanoma tumors, demonstrating a role for 'non-genomic' drivers in cancer evolution.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Year: 2015 PMID： 26440701 PMCID： PMC5104493 DOI： 10.1016/j.it.2015.09.003

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

10 in total

1. Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance.

Authors: Willy Hugo; Hubing Shi; Lu Sun; Marco Piva; Chunying Song; Xiangju Kong; Gatien Moriceau; Aayoung Hong; Kimberly B Dahlman; Douglas B Johnson; Jeffrey A Sosman; Antoni Ribas; Roger S Lo
Journal: Cell Date: 2015-09-10 Impact factor: 41.582

2. Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity.

Authors: Stefani Spranger; Riyue Bao; Thomas F Gajewski
Journal: Nature Date: 2015-05-11 Impact factor: 49.962

3. The prognostic landscape of genes and infiltrating immune cells across human cancers.

Authors: Andrew J Gentles; Aaron M Newman; Chih Long Liu; Scott V Bratman; Weiguo Feng; Dongkyoon Kim; Viswam S Nair; Yue Xu; Amanda Khuong; Chuong D Hoang; Maximilian Diehn; Robert B West; Sylvia K Plevritis; Ash A Alizadeh
Journal: Nat Med Date: 2015-07-20 Impact factor: 53.440

Review 4. Immune Checkpoint Blockade in Cancer Therapy.

Authors: Michael A Postow; Margaret K Callahan; Jedd D Wolchok
Journal: J Clin Oncol Date: 2015-01-20 Impact factor: 44.544

Review 5. Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?

Authors: Michael Hölzel; Anton Bovier; Thomas Tüting
Journal: Nat Rev Cancer Date: 2013-03-28 Impact factor: 60.716

6. Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.

Authors: Chih-Hao Chang; Jing Qiu; David O'Sullivan; Michael D Buck; Takuro Noguchi; Jonathan D Curtis; Qiongyu Chen; Mariel Gindin; Matthew M Gubin; Gerritje J W van der Windt; Elena Tonc; Robert D Schreiber; Edward J Pearce; Erika L Pearce
Journal: Cell Date: 2015-08-27 Impact factor: 41.582

7. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

Authors: Michael A Paley; Daniela C Kroy; Pamela M Odorizzi; Jonathan B Johnnidis; Douglas V Dolfi; Burton E Barnett; Elizabeth K Bikoff; Elizabeth J Robertson; Georg M Lauer; Steven L Reiner; E John Wherry
Journal: Science Date: 2012-11-30 Impact factor: 47.728

Review 8. Effects of BRAF mutations and BRAF inhibition on immune responses to melanoma.

Authors: Kristina M Ilieva; Isabel Correa; Debra H Josephs; Panagiotis Karagiannis; Isioma U Egbuniwe; Michiala J Cafferkey; James F Spicer; Mark Harries; Frank O Nestle; Katie E Lacy; Sophia N Karagiannis
Journal: Mol Cancer Ther Date: 2014-11-10 Impact factor: 6.261

9. The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells.

Authors: Hidetoshi Sumimoto; Fumie Imabayashi; Tomoko Iwata; Yutaka Kawakami
Journal: J Exp Med Date: 2006-06-26 Impact factor: 14.307

10. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

Authors: Ping-Chih Ho; Jessica Dauz Bihuniak; Andrew N Macintyre; Matthew Staron; Xiaojing Liu; Robert Amezquita; Yao-Chen Tsui; Guoliang Cui; Goran Micevic; Jose C Perales; Steven H Kleinstein; E Dale Abel; Karl L Insogna; Stefan Feske; Jason W Locasale; Marcus W Bosenberg; Jeffrey C Rathmell; Susan M Kaech
Journal: Cell Date: 2015-08-27 Impact factor: 41.582

10 in total

1 in total

Review 1. Immunological effect of tyrosine kinase inhibitors on the tumor immune environment in non-small cell lung cancer.

Authors: Li Jiang; Jiyan Liu
Journal: Oncol Lett Date: 2022-03-28 Impact factor: 2.967

1 in total