Literature DB >> 26439960

Gelsolin decreases actin toxicity and inflammation in murine multiple sclerosis.

Kevin Li-ChunHsieh1, Stefan Schob1, Matthias W G Zeller1, Benjamin Pulli1, Muhammad Ali1, Cuihua Wang1, Terry Ting-Yu Chiou2, Yuk-Ming Tsang3, Po-Shun Lee2, Thomas P Stossel2, John W Chen4.   

Abstract

Gelsolin is the fourth most abundant protein in the body and its depletion in the blood has been found in multiple sclerosis (MS) patients. How gelsolin affects the MS brain has not been studied. We found that while the secreted form of gelsolin (pGSN) decreased in the blood of experimental autoimmune encephalomyelitis (EAE) mice, pGSN concentration increased in the EAE brain. Recombinant human pGSN (rhp-GSN) decreased extracellular actin and myeloperoxidase activity in the brain, resulting in reduced disease activity and less severe clinical disease, suggesting that gelsolin could be a potential therapeutic target for MS.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Actin; Experimental autoimmune encephalomyelitis (EAE); Gelsolin; Inflammation; Magnetic resonance imaging; Myeloperoxidase

Mesh：

Substances：

Year:  2015        PMID： 26439960      PMCID： PMC4595933          DOI： 10.1016/j.jneuroim.2015.08.006

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  36 in total

1.  Plasma gelsolin is a marker and therapeutic agent in animal sepsis.

Authors:  Po-Shun Lee; Aaron B Waxman; Kara L Cotich; Su Wol Chung; Mark A Perrella; Thomas P Stossel
Journal:  Crit Care Med       Date:  2007-03       Impact factor: 7.598

2.  Inhibition of reactive astrocytosis in established experimental autoimmune encephalomyelitis favors infiltration by myeloid cells over T cells and enhances severity of disease.

Authors:  Henrik Toft-Hansen; Laila Füchtbauer; Trevor Owens
Journal:  Glia       Date:  2011-01       Impact factor: 7.452

3.  Plasma-type gelsolin is decreased in human blood and cerebrospinal fluid after subarachnoid hemorrhage.

Authors:  Sherry H-Y Chou; Po-Shun Lee; Rachael G Konigsberg; Dana Gallacci; Terry Chiou; Ken Arai; Suzanne Simmons; David Bauer; Steven K Feske; Eng H Lo; MingMing Ning
Journal:  Stroke       Date:  2011-09-22       Impact factor: 7.914

4.  Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target.

Authors:  Reza Forghani; Gregory R Wojtkiewicz; Yinian Zhang; Daniel Seeburg; Benjamin R M Bautz; Benjamin Pulli; Andrew R Milewski; Wendy L Atkinson; Yoshiko Iwamoto; Elizabeth R Zhang; Martin Etzrodt; Elisenda Rodriguez; Clinton S Robbins; Filip K Swirski; Ralph Weissleder; John W Chen
Journal:  Radiology       Date:  2012-03-21       Impact factor: 11.105

5.  Actin-containing sera from patients with adult respiratory distress syndrome are toxic to sheep pulmonary endothelial cells.

Authors:  J A Erukhimov; Z L Tang; B A Johnson; M P Donahoe; J A Razzack; K F Gibson; W M Lee; K J Wasserloos; S A Watkins; B R Pitt
Journal:  Am J Respir Crit Care Med       Date:  2000-07       Impact factor: 21.405

6.  Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin.

Authors:  Teresia M Osborn; Claes Dahlgren; John H Hartwig; Thomas P Stossel
Journal:  Am J Physiol Cell Physiol       Date:  2006-11-29       Impact factor: 4.249

7.  Multiple sclerosis: myeloperoxidase immunoradiology improves detection of acute and chronic disease in experimental model.

Authors:  Benjamin Pulli; Lionel Bure; Gregory R Wojtkiewicz; Yoshiko Iwamoto; Muhammad Ali; Dan Li; Stefan Schob; Kevin Li-Chun Hsieh; Andreas H Jacobs; John W Chen
Journal:  Radiology       Date:  2014-12-10       Impact factor: 11.105

8.  Hypogelsolinemia, a disorder of the extracellular actin scavenger system, in patients with multiple sclerosis.

Authors:  Alina Kułakowska; Nicholas J Ciccarelli; Qi Wen; Barbara Mroczko; Wiesław Drozdowski; Maciej Szmitkowski; Paul A Janmey; Robert Bucki
Journal:  BMC Neurol       Date:  2010-11-01       Impact factor: 2.474

9.  Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS.

Authors:  Rhonda R Voskuhl; R Scott Peterson; Bingbing Song; Yan Ao; Laurie Beth J Morales; Seema Tiwari-Woodruff; Michael V Sofroniew
Journal:  J Neurosci       Date:  2009-09-16       Impact factor: 6.167

10.  Measuring myeloperoxidase activity in biological samples.

Authors:  Benjamin Pulli; Muhammad Ali; Reza Forghani; Stefan Schob; Kevin L C Hsieh; Gregory Wojtkiewicz; Jenny J Linnoila; John W Chen
Journal:  PLoS One       Date:  2013-07-05       Impact factor: 3.240
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  11 in total

1.  Cytoskeletal Regulation of Oligodendrocyte Differentiation and Myelination.

Authors:  Tanya L Brown; Dylan R Verden
Journal:  J Neurosci       Date:  2017-08-16       Impact factor: 6.167

2.  Actin-Binding Protein Cortactin Promotes Pathogenesis of Experimental Autoimmune Encephalomyelitis by Supporting Leukocyte Infiltration into the Central Nervous System.

Authors:  Maryna Samus; Yu-Tung Li; Lydia Sorokin; Klemens Rottner; Dietmar Vestweber
Journal:  J Neurosci       Date:  2020-01-07       Impact factor: 6.167

Review 3.  β-Actin: An Emerging Biomarker in Ischemic Stroke.

Authors:  Jiaqian Li; Fangyu Dai; Xuelian Kou; Bin Wu; Jie Xu; Songbin He
Journal:  Cell Mol Neurobiol       Date:  2022-05-13       Impact factor: 5.046

4.  Safety and Pharmacokinetics of Recombinant Human Plasma Gelsolin in Patients Hospitalized for Nonsevere Community-Acquired Pneumonia.

Authors:  Abla Tannous; Susan L Levinson; James Bolognese; Steven M Opal; Mark J DiNubile
Journal:  Antimicrob Agents Chemother       Date:  2020-09-21       Impact factor: 5.191

5.  Plasma gelsolin levels in patients with psoriatic arthritis: a possible novel marker.

Authors:  Marwa M Esawy; Wafaa K Makram; Waleed Albalat; Marwa A Shabana
Journal:  Clin Rheumatol       Date:  2020-01-30       Impact factor: 2.980

6.  Gelsolin and Progression of Aortic Arch Calcification in Chronic Hemodialysis Patients.

Authors:  Terry Ting-Yu Chiou; Shang-Chih Liao; Yu-Yin Kao; Wen-Chin Lee; Yueh-Ting Lee; Hwee-Yeong Ng; Po-Shun Lee; Chien-Te Lee
Journal:  Int J Med Sci       Date:  2016-01-29       Impact factor: 3.738

7.  Overexpression of GSN could decrease inflammation and apoptosis in EAE and may enhance vitamin D therapy on EAE/MS.

Authors:  Jifang Gao; Zhaoyu Qin; Xinyuan Guan; Juanjuan Guo; Huaqing Wang; Shilian Liu
Journal:  Sci Rep       Date:  2017-04-04       Impact factor: 4.379

8.  Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women.

Authors:  Wen-Yu Wang; Bing Ge; Ju Shi; Xu Zhou; Long-Fei Wu; Chang-Hua Tang; Dong-Cheng Zhu; Hong Zhu; Xing-Bo Mo; Yong-Hong Zhang; Fei-Yan Deng; Shu-Feng Lei
Journal:  PLoS One       Date:  2018-05-22       Impact factor: 3.240

9.  Recombinant Human Plasma Gelsolin Stimulates Phagocytosis while Diminishing Excessive Inflammatory Responses in Mice with Pseudomonas aeruginosa Sepsis.

Authors:  Ewelina Piktel; Urszula Wnorowska; Mateusz Cieśluk; Piotr Deptuła; Suhanya V Prasad; Grzegorz Król; Bonita Durnaś; Andrzej Namiot; Karolina H Markiewicz; Katarzyna Niemirowicz-Laskowska; Agnieszka Z Wilczewska; Paul A Janmey; Joanna Reszeć; Robert Bucki
Journal:  Int J Mol Sci       Date:  2020-04-07       Impact factor: 5.923

Review 10.  Plasma Gelsolin: Indicator of Inflammation and Its Potential as a Diagnostic Tool and Therapeutic Target.

Authors:  Ewelina Piktel; Ilya Levental; Bonita Durnaś; Paul A Janmey; Robert Bucki
Journal:  Int J Mol Sci       Date:  2018-08-25       Impact factor: 5.923
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