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Literature DB >> 26439637

SEC-uring membrane fusion: a sneak peek at SNARE-complex assembly driven by Sec1-Munc18 proteins.

Brett M Collins¹, Jennifer L Martin¹.

Abstract

Entities: Gene

Mesh：

Substances：

Year: 2015 PMID： 26439637 DOI： 10.1038/nsmb.3094

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

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15 in total

1. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation.

Authors: Shu-Hong Hu; Michelle P Christie; Natalie J Saez; Catherine F Latham; Russell Jarrott; Linda H L Lua; Brett M Collins; Jennifer L Martin
Journal: Proc Natl Acad Sci U S A Date: 2010-12-30 Impact factor: 11.205

2. Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide.

Authors: Pawel Burkhardt; Douglas A Hattendorf; William I Weis; Dirk Fasshauer
Journal: EMBO J Date: 2008-03-13 Impact factor: 11.598

3. The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane.

Authors: Sally Martin; Vanesa M Tomatis; Andreas Papadopulos; Michelle P Christie; Nancy T Malintan; Rachel S Gormal; Shuzo Sugita; Jennifer L Martin; Brett M Collins; Frederic A Meunier
Journal: J Cell Sci Date: 2013-06-01 Impact factor: 5.285

SEC-uring membrane fusion: a sneak peek at SNARE-complex assembly driven by Sec1-Munc18 proteins.

1. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation.

2. Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide.

3. The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane.

4. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution.

5. Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.

6. Domain 3a of Munc18-1 plays a crucial role at the priming stage of exocytosis.

7. From fission to fusion: a perspective on the research that won the Nobel Prize in Physiology or Medicine, 2013.

8. Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex.

9. A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly.

10. Binding of Munc18-1 to synaptobrevin and to the SNARE four-helix bundle.

1. Munc13 activates the Munc18-1/syntaxin-1 complex and enables Munc18-1 to prime SNARE assembly.