Literature DB >> 26439516

QSAR model for predicting cell viability of human embryonic kidney cells exposed to SiO₂ nanoparticles.

Serena Manganelli1, Caterina Leone2, Andrey A Toropov2, Alla P Toropova2, Emilio Benfenati2.   

Abstract

A predictive model for the viability (%) of cultured human embryonic kidney cells (HEK293) exposed to 20 and 50 nm silica nanoparticles was built using 'optimal descriptors' as mathematical functions of size, concentration and exposure time. The calculation was carried out with CORAL software (http://www.insilico.eu/coral/) on five random splits of combined systems (particle size-particle concentration-cell exposure time) into training, calibration, and validation sets. The R(2) values of the best models were above 0.68. The average statistical quality of the model for the viability (%) of HEK293 exposed to different concentrations of silica nanoparticles measured by MTT assay is satisfactory.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  CORAL software; Cell viability; NanoQSAR; Quasi-SMILES; Silica nanoparticle

Mesh：

Substances：

Year:  2015        PMID： 26439516     DOI： 10.1016/j.chemosphere.2015.09.086

Source DB:  PubMed          Journal:  Chemosphere        ISSN： 0045-6535            Impact factor:   7.086


  6 in total

1.  Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).

Authors:  Georgia Melagraki; Evangelos Ntougkos; Vagelis Rinotas; Christos Papaneophytou; Georgios Leonis; Thomas Mavromoustakos; George Kontopidis; Eleni Douni; Antreas Afantitis; George Kollias
Journal:  PLoS Comput Biol       Date:  2017-04-20       Impact factor: 4.475

2.  Towards a generalized toxicity prediction model for oxide nanomaterials using integrated data from different sources.

Authors:  Jang-Sik Choi; My Kieu Ha; Tung Xuan Trinh; Tae Hyun Yoon; Hyung-Gi Byun
Journal:  Sci Rep       Date:  2018-04-17       Impact factor: 4.379

Review 3.  A health concern regarding the protein corona, aggregation and disaggregation.

Authors:  Mojtaba Falahati; Farnoosh Attar; Majid Sharifi; Thomas Haertlé; Jean-François Berret; Rizwan Hasan Khan; Ali Akbar Saboury
Journal:  Biochim Biophys Acta Gen Subj       Date:  2019-02-22       Impact factor: 3.770

Review 4.  NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment.

Authors:  Antreas Afantitis; Georgia Melagraki; Panagiotis Isigonis; Andreas Tsoumanis; Dimitra Danai Varsou; Eugenia Valsami-Jones; Anastasios Papadiamantis; Laura-Jayne A Ellis; Haralambos Sarimveis; Philip Doganis; Pantelis Karatzas; Periklis Tsiros; Irene Liampa; Vladimir Lobaskin; Dario Greco; Angela Serra; Pia Anneli Sofia Kinaret; Laura Aliisa Saarimäki; Roland Grafström; Pekka Kohonen; Penny Nymark; Egon Willighagen; Tomasz Puzyn; Anna Rybinska-Fryca; Alexander Lyubartsev; Keld Alstrup Jensen; Jan Gerit Brandenburg; Stephen Lofts; Claus Svendsen; Samuel Harrison; Dieter Maier; Kaido Tamm; Jaak Jänes; Lauri Sikk; Maria Dusinska; Eleonora Longhin; Elise Rundén-Pran; Espen Mariussen; Naouale El Yamani; Wolfgang Unger; Jörg Radnik; Alexander Tropsha; Yoram Cohen; Jerzy Leszczynski; Christine Ogilvie Hendren; Mark Wiesner; David Winkler; Noriyuki Suzuki; Tae Hyun Yoon; Jang-Sik Choi; Natasha Sanabria; Mary Gulumian; Iseult Lynch
Journal:  Comput Struct Biotechnol J       Date:  2020-03-07       Impact factor: 7.271

Review 5.  Nano-(Q)SAR for Cytotoxicity Prediction of Engineered Nanomaterials.

Authors:  Andrey A Buglak; Anatoly V Zherdev; Boris B Dzantiev
Journal:  Molecules       Date:  2019-12-11       Impact factor: 4.411

6.  The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies.

Authors:  Xuemeng Dong; Zehao Wu; Xiuping Li; Liyan Xiao; Man Yang; Yang Li; Junchao Duan; Zhiwei Sun
Journal:  Int J Nanomedicine       Date:  2020-11-18
  6 in total

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