Literature DB >> 26439291

One of these is not like the others.

Martin S Pavelka1.   

Abstract

A Mycobacterium tuberculosis metA mutant that is auxotrophic for methionine is unlike other auxotrophic mutants of this important species as methionine starvation results in rapid death instead of cessation of growth. Evidence suggests that this phenotype results from starvation affecting essential pathways that utilize S-adenosylmethionine in addition to methionine.
Copyright © 2015 Elsevier Ltd. All rights reserved.

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Keywords:  S-adenosylmethionine; auxotroph; methionine; tuberculosis

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Year:  2015        PMID: 26439291     DOI: 10.1016/j.tim.2015.09.005

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN: 0966-842X            Impact factor:   17.079


  1 in total

1.  Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site.

Authors:  Catherine T Chaton; Emily S Rodriguez; Robert W Reed; Jian Li; Cameron W Kenner; Konstantin V Korotkov
Journal:  Sci Rep       Date:  2019-12-30       Impact factor: 4.379

  1 in total

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