Literature DB >> 26438397

Statin reduces orbitopathy risk in patients with Graves' disease by modulating apoptosis and autophagy activities.

Maurizio Bifulco1, Elena Ciaglia2.   

Abstract

Statins use has been associated with reduced risk for developing orbitopathy among patients with Graves' disease. We hypothesize that statin reduces orbitopathy risk mainly by modulating both apoptosis and autophagy activities in patients with Graves' disease.

Entities:  

Keywords:  Autophagy; Graves’ orbitopathy; Statins

Mesh：

Substances：

Year:  2015        PMID： 26438397     DOI： 10.1007/s12020-015-0762-z

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.633


  11 in total

Review 1.  Innate immune activation and thyroid autoimmunity.

Authors:  Akira Kawashima; Kazunari Tanigawa; Takeshi Akama; Aya Yoshihara; Norihisa Ishii; Koichi Suzuki
Journal:  J Clin Endocrinol Metab       Date:  2011-09-28       Impact factor: 5.958

2.  Simvastatin alleviates the progression of periapical lesions by modulating autophagy and apoptosis in osteoblasts.

Authors:  Eddie Hsiang-Hua Lai; Chi-Yuan Hong; Sang-Heng Kok; Kuo-Liang Hou; Ling-Hsiu Chao; Li-Deh Lin; Mu-Hsiung Chen; Ping-Han Wu; Sze-Kwan Lin
Journal:  J Endod       Date:  2012-04-06       Impact factor: 4.171

3.  Molecular pathology of Muller's muscle in Graves' ophthalmopathy.

Authors:  Mei-Ju Shih; Shu-Lang Liao; Kuan-Ting Kuo; Terry J Smith; Lee-Ming Chuang
Journal:  J Clin Endocrinol Metab       Date:  2005-12-29       Impact factor: 5.958

4.  Autophagy is involved in the initiation and progression of Graves' orbitopathy.

Authors:  Jin Sook Yoon; Hyun Jung Lee; Min Kyung Chae; Eun Jig Lee
Journal:  Thyroid       Date:  2015-04       Impact factor: 6.568

Review 5.  Novel aspects of mevalonate pathway inhibitors as antitumor agents.

Authors:  Martin Thurnher; Oliver Nussbaumer; Georg Gruenbacher
Journal:  Clin Cancer Res       Date:  2012-04-23       Impact factor: 12.531

6.  Risk factors for developing thyroid-associated ophthalmopathy among individuals with Graves disease.

Authors:  Joshua D Stein; David Childers; Shivani Gupta; Nidhi Talwar; Bin Nan; Brian J Lee; Terry J Smith; Raymond Douglas
Journal:  JAMA Ophthalmol       Date:  2015-03       Impact factor: 7.389

7.  Effect of statins on the viability of macrophages and smooth muscle cells.

Authors:  Valerie Croons; Inge De Meyer; Sander M Houten; Wim Martinet; Hidde Bult; Arnold G Herman; Guido R Y De Meyer
Journal:  J Cardiovasc Pharmacol       Date:  2010-03       Impact factor: 3.105

8.  Apoptosis in orbital fibroadipose tissue and its association with clinical features in Graves' ophthalmopathy.

Authors:  Onur Konuk; Ahmet Hondur; Nalan Akyurek; Mehmet Unal
Journal:  Ocul Immunol Inflamm       Date:  2007 Mar-Apr       Impact factor: 3.070

9.  Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53.

Authors:  Saeid Ghavami; Mark M Mutawe; Pawan Sharma; Behzad Yeganeh; Karol D McNeill; Thomas Klonisch; Helmut Unruh; Hessam H Kashani; Dedmer Schaafsma; Marek Los; Andrew J Halayko
Journal:  PLoS One       Date:  2011-01-31       Impact factor: 3.240

10.  Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts.

Authors:  S Ghavami; B Yeganeh; G L Stelmack; H H Kashani; P Sharma; R Cunnington; S Rattan; K Bathe; T Klonisch; I M C Dixon; D H Freed; A J Halayko
Journal:  Cell Death Dis       Date:  2012-06-21       Impact factor: 8.469
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  5 in total

1.  Relationship between serum cholesterol and Graves' orbitopathy (GO): a confirmatory study.

Authors:  G Lanzolla; E Sabini; M A Profilo; B Mazzi; A Sframeli; R Rocchi; F Menconi; M Leo; M Nardi; P Vitti; C Marcocci; M Marinò
Journal:  J Endocrinol Invest       Date:  2018-06-19       Impact factor: 4.256

Review 2.  The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword.

Authors:  Peiwei Chai; Hongyan Ni; He Zhang; Xianqun Fan
Journal:  Int J Biol Sci       Date:  2016-10-25       Impact factor: 6.580

Review 3.  Cholesterol Serum Levels and Use of Statins in Graves' Orbitopathy: A New Starting Point for the Therapy.

Authors:  Giulia Lanzolla; Guia Vannucchi; Ilaria Ionni; Irene Campi; Federica Sileo; Elisa Lazzaroni; Michele Marinò
Journal:  Front Endocrinol (Lausanne)       Date:  2020-01-22       Impact factor: 5.555

4.  Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves' Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways.

Authors:  Yi-Hsuan Wei; Shu-Lang Liao; Sen-Hsu Wang; Chia-Chun Wang; Chang-Hao Yang
Journal:  Front Endocrinol (Lausanne)       Date:  2021-02-01       Impact factor: 5.555

Review 5.  Thyroid eye disease: From pathogenesis to targeted therapies.

Authors:  Jin Sook Yoon; Don O Kikkawa
Journal:  Taiwan J Ophthalmol       Date:  2022-01-21
  5 in total

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