Othman Al-Helli1, David L Thomas2, Luke Massey3,4, Thomas Foltynie5, Patricia Limousin5, Janice L Holton6, Tarek A Yousry2,7, Ludvic Zrinzo5. 1. Neuroradiology Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, 8-11 Queen Square, London, WC1n 3BG, UK. othmanalhelli@gmail.com. 2. Neuroradiology Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, 8-11 Queen Square, London, WC1n 3BG, UK. 3. Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK. 4. Sara Koe PSP Research Centre, UCL Institute of Neurology, London, UK. 5. Unit of Functional Neurosurgery, UCL Institute of Neurology, London, UK. 6. Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, London, UK. 7. Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK.
Abstract
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) using an MRI-guided and MRI-verified technique without microelectrode recording is an effective and safe surgical treatment for patients with Parkinson's disease (PD). OBJECTIVES: To assess the anatomical accuracy of lead placement after MRI-guided, MRI-verified STN DBS using post-mortem histology and high-field MRI at 9.4 T. METHODS: We conducted post-mortem analysis of a patient's brain who had had MRI-guided, MRI-verified STN DBS for PD, using 9.4-T MRI and histology. After death, the brain was retrieved and a block including the electrode tracks down to the mesencephalon was examined with high-field MRI at 9.4 T and histological analysis. RESULTS: High-field MRI images and corresponding histological examination showed that each electrode track ended within the intended target area, and that DBS did not cause significant neuroparenchymal tissue damage. CONCLUSIONS: This study supports the anatomical accuracy of the MRI-guided and MRI-verified method of STN DBS.
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) using an MRI-guided and MRI-verified technique without microelectrode recording is an effective and safe surgical treatment for patients with Parkinson's disease (PD). OBJECTIVES: To assess the anatomical accuracy of lead placement after MRI-guided, MRI-verified STN DBS using post-mortem histology and high-field MRI at 9.4 T. METHODS: We conducted post-mortem analysis of a patient's brain who had had MRI-guided, MRI-verified STN DBS for PD, using 9.4-T MRI and histology. After death, the brain was retrieved and a block including the electrode tracks down to the mesencephalon was examined with high-field MRI at 9.4 T and histological analysis. RESULTS: High-field MRI images and corresponding histological examination showed that each electrode track ended within the intended target area, and that DBS did not cause significant neuroparenchymal tissue damage. CONCLUSIONS: This study supports the anatomical accuracy of the MRI-guided and MRI-verified method of STN DBS.
Entities:
Keywords:
Deep brain stimulation; Parkinson’s disease; Post-mortem; Subthalamic nucleus