Bakri Elsheikh1, W David Arnold2,3,4, Shahram Gharibshahi5, Jerold Reynolds2, Miriam Freimer2, John T Kissel2,4. 1. Neurology, Johns Hopkins Aramco Healthcare, Saudi Aramco, P.O. Box 2614, Dhahran, Saudi Arabia, 31311. 2. Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. 3. Department of Physical Medicine and Rehabilitation, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. 4. Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. 5. Neurology, Kaiser Permanente Neurology, Panorama City, California, USA.
Abstract
INTRODUCTION: Although formal spirometry is the gold standard for monitoring respiratory function in patients with myasthenia gravis (MG), such testing is often delayed or unavailable. There is a need for a simple bedside test that can accurately measure respiratory function. METHODS: We conducted a prospective, cross-sectional, single-blind study in adults with acetylcholine receptor antibody positive MG. Participants performed the single breath count test (SBCT) and underwent manual muscle strength testing, and a respiratory therapist performed spirometry blinded to SBCT and strength results. RESULTS: Thirty-one patients, aged 57 ± 19 years participated. SBCT showed significant correlations with forced vital capacity (FVC), negative inspiratory force, and neck flexor strength (P < 0.01). FVC showed significant correlation with neck flexor strength (P = 0.02) but no correlation with shoulder abductor strength. CONCLUSIONS: These data suggest that the SBCT and neck flexor strength testing are valuable tools for bedside assessment of respiratory function in MG patients.
INTRODUCTION: Although formal spirometry is the gold standard for monitoring respiratory function in patients with myasthenia gravis (MG), such testing is often delayed or unavailable. There is a need for a simple bedside test that can accurately measure respiratory function. METHODS: We conducted a prospective, cross-sectional, single-blind study in adults with acetylcholine receptor antibody positive MG. Participants performed the single breath count test (SBCT) and underwent manual muscle strength testing, and a respiratory therapist performed spirometry blinded to SBCT and strength results. RESULTS: Thirty-one patients, aged 57 ± 19 years participated. SBCT showed significant correlations with forced vital capacity (FVC), negative inspiratory force, and neck flexor strength (P < 0.01). FVC showed significant correlation with neck flexor strength (P = 0.02) but no correlation with shoulder abductor strength. CONCLUSIONS: These data suggest that the SBCT and neck flexor strength testing are valuable tools for bedside assessment of respiratory function in MGpatients.
Authors: C E Thomas; S A Mayer; Y Gungor; R Swarup; E A Webster; I Chang; T H Brannagan; M E Fink; L P Rowland Journal: Neurology Date: 1997-05 Impact factor: 9.910
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