| Literature DB >> 26437692 |
Luis Casarrubios1, Miguel A Esteruelas2, Carmen Larramona3, Agustí Lledós4, Jaime G Muntaner1, Enrique Oñate3, Manuel A Ortuño5, Miguel A Sierra6.
Abstract
The mechanism of OsH6(PiPr3)2-mediated fragmentation of a 4-(2 pyridyl)-2-azetidinone has been investigated by DFT calculations. The addition of the C4-H bond of the substrate to OsH2(PiPr3)2 allows the active participation of an osmium lone pair in the B-type β-lactam fragmentation process. This new mechanism makes the N1-C4/C2-C3 fragmentation of the lactamic core thermally accessible through a stepwise process.Entities:
Keywords: azetidinone; density functional calculations; hexahydride; osmium; β-lactam fragmentation
Year: 2015 PMID： 26437692 DOI： 10.1002/chem.201503595
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236