| Literature DB >> 26437592 |
Viviana I Risca1, William J Greenleaf2.
Abstract
Paired-end sequencing has enabled a variety of new methods for high-throughput interrogation of both genome structure and chromatin architecture. Here, we discuss how the paired-end paradigm can be used to interpret sequencing data as biophysical measurements of in vivo chromatin structure that report on single molecules in single cells.Entities:
Keywords: chromatin; chromosome structure; in vivo measurements; paired-end sequencing
Mesh:
Year: 2015 PMID: 26437592 PMCID: PMC5540433 DOI: 10.1016/j.tcb.2015.08.004
Source DB: PubMed Journal: Trends Cell Biol ISSN: 0962-8924 Impact factor: 20.808