Literature DB >> 26437588

The Functions of MicroRNAs: mRNA Decay and Translational Repression.

Hiro-Oki Iwakawa1, Yukihide Tomari2.   

Abstract

MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs, which regulate complementary mRNAs by inducing translational repression and mRNA decay. Although this dual repression system seems to operate in both animals and plants, genetic and biochemical studies suggest that the mechanism underlying the miRNA-mediated silencing is different in the two kingdoms. Here, we review the recent progress in our understanding of how miRNAs mediate translational repression and mRNA decay, and discuss the contributions of the two silencing modes to the overall silencing effect in both kingdoms.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Keywords:  AGO; Argonaute; RISC; RNA silencing; miRNA; plant

Mesh：

Substances：

Year:  2015        PMID： 26437588     DOI： 10.1016/j.tcb.2015.07.011

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  256 in total

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2.  NMDA receptor-dependent dephosphorylation of serine 387 in Argonaute 2 increases its degradation and affects dendritic spine density and maturation.

Authors:  Nicolas Paradis-Isler; Jannic Boehm
Journal:  J Biol Chem       Date:  2018-05-07       Impact factor: 5.157

3.  3' Uridylation Confers miRNAs with Non-canonical Target Repertoires.

Authors:  Acong Yang; Xavier Bofill-De Ros; Tie-Juan Shao; Minjie Jiang; Katherine Li; Patricia Villanueva; Lisheng Dai; Shuo Gu
Journal:  Mol Cell       Date:  2019-06-06       Impact factor: 17.970

4.  Systematic evaluation of the microRNAome through miR-CATCHv2.0 identifies positive and negative regulators of BRAF-X1 mRNA.

Authors:  Andrea Marranci; Romina D'Aurizio; Sebastian Vencken; Serena Mero; Elena Guzzolino; Milena Rizzo; Letizia Pitto; Marco Pellegrini; Giovanna Chiorino; Catherine M Greene; Laura Poliseno
Journal:  RNA Biol       Date:  2019-04-19       Impact factor: 4.652

5.  High-Throughput Identification of miRNA-Target Interactions in Melanoma Using miR-CATCHv2.0.

Authors:  Andrea Marranci; Romina D'Aurizio; Milena Rizzo; Catherine M Greene; Laura Poliseno
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Review 6.  The RNA world of human ageing.

Authors:  J C Gomez-Verjan; E R Vazquez-Martinez; N A Rivero-Segura; R H Medina-Campos
Journal:  Hum Genet       Date:  2018-11-01       Impact factor: 4.132

Review 7.  RNA uridylation and decay in plants.

Authors:  Caroline de Almeida; Hélène Scheer; Anthony Gobert; Veronica Fileccia; Federico Martinelli; Hélène Zuber; Dominique Gagliardi
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-11-05       Impact factor: 6.237

Review 8.  Targeting RNA in mammalian systems with small molecules.

Authors:  Anita Donlic; Amanda E Hargrove
Journal:  Wiley Interdiscip Rev RNA       Date:  2018-05-03       Impact factor: 9.957

9.  Magnaporthe oryzae Induces the Expression of a MicroRNA to Suppress the Immune Response in Rice.

Authors:  Xin Zhang; Yalin Bao; Deqi Shan; Zhihui Wang; Xiaoning Song; Zhaoyun Wang; Jiansheng Wang; Liqiang He; Liang Wu; Zhengguang Zhang; Dongdong Niu; Hailing Jin; Hongwei Zhao
Journal:  Plant Physiol       Date:  2018-03-16       Impact factor: 8.340

Review 10.  Pancreatic cancer stem cell markers and exosomes - the incentive push.

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Journal:  World J Gastroenterol       Date:  2016-07-14       Impact factor: 5.742
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