Ming Zhang1, Yali Li2, Jie Zhang2, Qiuhong Zhang2, Xia Yang2, Hu Shan2, Yingying Xie2, Qingzhi Jin2, Xiangli Feng2. 1. Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: zhangmingdr@163.com. 2. Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Abstract
BACKGROUND: Mean platelet volume (MPV), reflecting the platelet production rate and stimulation, is an inflammatory marker for cardiovascular disease, inflammatory bowel disease, and rheumatoid arthritis. However, the associations between MPV and chronic obstructive pulmonary disease (COPD) are not in agreement. METHODS: Ninety participants with an exacerbation of COPD were investigated, and were reassessed when convalescent. Ninety controls were matched for age, gender, body mass index, smoking index, and medication use. Blood samples were collected for measurements of MPV and other laboratory data, and pulmonary function was also assessed. RESULTS: MPV is significantly increased in convalescent COPD patients compared with healthy controls, and further increased in COPD patients with an acute exacerbation. MPV was positively correlated with high-sensitivity C-reactive protein both in the exacerbation and convalescence periods of COPD, and negatively correlated with FEV1 % predicted and FEV1/FVC in the convalescent COPD patients. CONCLUSIONS: MPV may be regarded as a quick and reliable tool in the assessment of inflammatory response in the progression of COPD.
BACKGROUND: Mean platelet volume (MPV), reflecting the platelet production rate and stimulation, is an inflammatory marker for cardiovascular disease, inflammatory bowel disease, and rheumatoid arthritis. However, the associations between MPV and chronic obstructive pulmonary disease (COPD) are not in agreement. METHODS: Ninety participants with an exacerbation of COPD were investigated, and were reassessed when convalescent. Ninety controls were matched for age, gender, body mass index, smoking index, and medication use. Blood samples were collected for measurements of MPV and other laboratory data, and pulmonary function was also assessed. RESULTS: MPV is significantly increased in convalescent COPDpatients compared with healthy controls, and further increased in COPDpatients with an acute exacerbation. MPV was positively correlated with high-sensitivity C-reactive protein both in the exacerbation and convalescence periods of COPD, and negatively correlated with FEV1 % predicted and FEV1/FVC in the convalescent COPDpatients. CONCLUSIONS: MPV may be regarded as a quick and reliable tool in the assessment of inflammatory response in the progression of COPD.
Authors: Maha Fathy Mohamed; Asmaa Ali; Ahmad Abbas; Mohammad Shafiq Awad; Mohammad Gouda; Amany M Sediq Journal: Int J Chron Obstruct Pulmon Dis Date: 2019-05-23
Authors: Lisandra Torres Hartmann; Ana Paula Alegretti; Alice Beatriz Mombach Pinheiro Machado; Eduardo Ferreira Martins; Rafael Mendonça da Silva Chakr; Andrese Aline Gasparin; Odirlei André Monticielo Journal: Open Rheumatol J Date: 2018-08-31