Anitha Balaji1, Thodur Madapusi Balaji2, Suresh Ranga Rao3. 1. Professor, Department of Periodontology, Shree Balaji Dental College and Hospital , Pallikaranai, Chennai, Tamil Nadu, India . 2. Associate Professor, Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University , Porur, Chennai, Tamil Nadu, India . 3. Professor and Head, Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University , Porur, Chennai, Tamil Nadu, India .
Abstract
CONTEXT: The Renin Angiotensin system has been implicated in the pathogenesis of Drug Induced Gingival Overgrowth (DIGO), a fibrotic condition, caused by Phenytoin, Nifedipine and Cyclosporine. AIM: This study quantified Angiotensin II levels in gingival tissue samples obtained from healthy individuals, patients on Nifedipine manifesting/not manifesting drug induced gingival overgrowth. MATERIALS AND METHODS: Gingival tissue samples were obtained from healthy individuals (n=24), patients on nifidipine manifesting gingival overgrowth (n= 18) and patients on nifidipine not manifesting gingival overgrowth (n=8). Angiotensin II levels were estimated in the samples using a commercially available ELISA kit. RESULTS: Angiotensin II levels were significantly elevated in patients on Nifedipine manifesting gingival overgrowth compared to the other 2 groups (p<0.01). CONCLUSION: The results of the study give an insight into the role played by Angiotensin II in the pathogenesis of drug induced gingival overgrowth.
CONTEXT: The Renin Angiotensin system has been implicated in the pathogenesis of Drug Induced Gingival Overgrowth (DIGO), a fibrotic condition, caused by Phenytoin, Nifedipine and Cyclosporine. AIM: This study quantified Angiotensin II levels in gingival tissue samples obtained from healthy individuals, patients on Nifedipine manifesting/not manifesting drug induced gingival overgrowth. MATERIALS AND METHODS: Gingival tissue samples were obtained from healthy individuals (n=24), patients on nifidipine manifesting gingival overgrowth (n= 18) and patients on nifidipine not manifesting gingival overgrowth (n=8). Angiotensin II levels were estimated in the samples using a commercially available ELISA kit. RESULTS:Angiotensin II levels were significantly elevated in patients on Nifedipine manifesting gingival overgrowth compared to the other 2 groups (p<0.01). CONCLUSION: The results of the study give an insight into the role played by Angiotensin II in the pathogenesis of drug induced gingival overgrowth.
Authors: I Cebeci; A Kantarci; E Firatli; S Aygün; H Tanyeri; A E Aydin; M Carin; U Güç; O Tuncer Journal: J Clin Periodontol Date: 1996-08 Impact factor: 8.728
Authors: C F Santos; A E Akashi; T J Dionísio; C R Sipert; D N Didier; A S Greene; S H P Oliveira; H J V Pereira; C Becari; E B Oliveira; M C O Salgado Journal: J Periodontol Date: 2009-01 Impact factor: 6.993