Sathish Manthena1, Mulpuri Venkata Ramoji Rao2, Lakshmi Preethi Penubolu1, Madhusudhan Putcha3, Anumolu Venkata Naga Sri Harsha3. 1. Reader, Department of Periodontics, Drs. Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences , Chinnoutpalli, India . 2. Professor and Head, Department of Periodontics, Drs. Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences , Chinnoutpalli, India . 3. Senior Lecturer, Department of Periodontics, Drs. Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences , Chinnoutpalli, India .
Abstract
INTRODUCTION: Deficiency of CoQ 10 was found in human inflamed gingiva and has been found to be responsible for periodontal destruction. AIM: To evaluate the effectiveness of CoQ 10 supplementation as an adjunct to scaling and rootplaning in reducing gingival inflammation and periodontal pocket depth. MATERIALS AND METHODS: The study was a randomized, double-blind, controlled, parallel group design clinical trial. Thirty subjects with plaque induced gingival inflammation and having atleast three nonadjacent interproximal sites with a probing pocket depth ≥ 5mm were included in the study. The subjects were randomly divided into two groups. The test group (n=15) in which patients were given oral CoQ10 supplements after scaling and root planing and the control group (n=15) in which patients were given an oral placebo after scaling and rootplaning. The plaque index, gingival index and probing depth were recorded at baseline, 1 month and 3 months. Statistical analysis done by using Student's paired t-test for intragroup comparison and unpaired t-test for inter-group comparison. RESULTS: Both the groups showed marked reduction of afore mentioned periodontal parameters at one month and three months when compared to baseline. Though there was no significant difference in plaque index and probing pocket depth between the two groups at any given time period, test group showed significant difference in gingival inflammation at one month and three months when compared to control group. CONCLUSION: In the present study use of Coenzyme Q10 oral supplements as an adjunct to scaling and root planing showed significant reduction in gingival inflammation when compared to scaling and rootplaning alone.
RCT Entities:
INTRODUCTION: Deficiency of CoQ 10 was found in human inflamed gingiva and has been found to be responsible for periodontal destruction. AIM: To evaluate the effectiveness of CoQ 10 supplementation as an adjunct to scaling and rootplaning in reducing gingival inflammation and periodontal pocket depth. MATERIALS AND METHODS: The study was a randomized, double-blind, controlled, parallel group design clinical trial. Thirty subjects with plaque induced gingival inflammation and having atleast three nonadjacent interproximal sites with a probing pocket depth ≥ 5mm were included in the study. The subjects were randomly divided into two groups. The test group (n=15) in which patients were given oral CoQ10 supplements after scaling and root planing and the control group (n=15) in which patients were given an oral placebo after scaling and rootplaning. The plaque index, gingival index and probing depth were recorded at baseline, 1 month and 3 months. Statistical analysis done by using Student's paired t-test for intragroup comparison and unpaired t-test for inter-group comparison. RESULTS: Both the groups showed marked reduction of afore mentioned periodontal parameters at one month and three months when compared to baseline. Though there was no significant difference in plaque index and probing pocket depth between the two groups at any given time period, test group showed significant difference in gingival inflammation at one month and three months when compared to control group. CONCLUSION: In the present study use of Coenzyme Q10 oral supplements as an adjunct to scaling and root planing showed significant reduction in gingival inflammation when compared to scaling and rootplaning alone.