Siamak Yaghoobi1, Marzieh Beigom Khezri2, Azam Mohammadi Alamouti3. 1. Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Qazvin Medical University Science , Iran . 2. Associate Professor, Department of Anesthesiology, Faculty of Medicine, Qazvin Medical University Science , Iran . 3. MS in Critical Care Nursing, Department of Critical Care Unit, Rajaei Hospital, Qazvin University of Medical Science , Qazvin, Iran .
Abstract
BACKGROUND: One of the most important therapeutic maneuvers in head injury patients is to maintain Intracranial Pressure (ICP) and Cerebral Perfusion Pressure (CPP) within normal levels. AIMS: To compare the effects of low dose of thiopental sodium and propofol on reducing ICP and CPP in patients with head injury that scheduled for neurosurgical interventions. SETTINGS AND DESIGN: Using a randomized, crossover pilot study, we enrolled patients with head injury that scheduled for neurosurgical interventions admitted to ICU unit of a teaching hospital during 2010 to 2011. MATERIALS AND METHODS: In this pilot study, patients randomized into two equal groups. The first group received bolus injection of thiopental sodium 2 mg/kg and a maintenance dose of 2 mg/kg/h and the second group was given a bolus dose of propofol 0.5 mg/kg followed by propofol infusion 20 μg/kg/min. All of patients were given dexamethasone 8 mg at time of catheter insertion. ICP measurement catheter was inserted for each patient and ICP, CPP, SPO2 and MAP were recorded hourly for a period of 6 hours. RESULTS: There was no significant difference in sex and age between the two study groups (p>0.05). The mean ICP, CPP, SPO2 and arterial blood pressure were found to be similar with no significant difference between both groups (p>0.05). CONCLUSION: Both propofol and thiopental sodium were equally effective in monitoring and maintaining CPP and MAP and eventually an ideal SPO2.
RCT Entities:
BACKGROUND: One of the most important therapeutic maneuvers in head injurypatients is to maintain Intracranial Pressure (ICP) and Cerebral Perfusion Pressure (CPP) within normal levels. AIMS: To compare the effects of low dose of thiopental sodium and propofol on reducing ICP and CPP in patients with head injury that scheduled for neurosurgical interventions. SETTINGS AND DESIGN: Using a randomized, crossover pilot study, we enrolled patients with head injury that scheduled for neurosurgical interventions admitted to ICU unit of a teaching hospital during 2010 to 2011. MATERIALS AND METHODS: In this pilot study, patients randomized into two equal groups. The first group received bolus injection of thiopental sodium 2 mg/kg and a maintenance dose of 2 mg/kg/h and the second group was given a bolus dose of propofol 0.5 mg/kg followed by propofol infusion 20 μg/kg/min. All of patients were given dexamethasone 8 mg at time of catheter insertion. ICP measurement catheter was inserted for each patient and ICP, CPP, SPO2 and MAP were recorded hourly for a period of 6 hours. RESULTS: There was no significant difference in sex and age between the two study groups (p>0.05). The mean ICP, CPP, SPO2 and arterial blood pressure were found to be similar with no significant difference between both groups (p>0.05). CONCLUSION: Both propofol and thiopental sodium were equally effective in monitoring and maintaining CPP and MAP and eventually an ideal SPO2.
Authors: François Girard; Robert Moumdjian; Daniel Boudreault; Philippe Chouinard; Alain Bouthilier; Eric Sauvageau; Monique Ruel; Dominique C Girard Journal: Anesth Analg Date: 2004-08 Impact factor: 5.108
Authors: Anneliese Synnot; Peter Bragge; Carole Lunny; David Menon; Ornella Clavisi; Loyal Pattuwage; Victor Volovici; Stefania Mondello; Maryse C Cnossen; Emma Donoghue; Russell L Gruen; Andrew Maas Journal: PLoS One Date: 2018-06-21 Impact factor: 3.240