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Literature DB >> 26434808

Synthetic multivalency for biological applications.

Abstract

Current directions and emerging possibilities under investigation for the integration of synthetic and semi-synthetic multivalent architectures with biology are discussed. Attention is focussed around multivalent interactions, their fundamental role in biology, and current and potential approaches in emulating them in terms of structure and functionality using synthetic architectures.

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Year: 2015 PMID： 26434808 DOI： 10.1039/c5ob01357g

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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Cited

10 in total

1. Engineering peptide-targeted liposomal nanoparticles optimized for improved selectivity for HER2-positive breast cancer cells to achieve enhanced in vivo efficacy.

Authors: Baksun Kim; Jaeho Shin; Junmin Wu; David T Omstead; Tanyel Kiziltepe; Laurie E Littlepage; Basar Bilgicer
Journal: J Control Release Date: 2020-04-08 Impact factor: 9.776

2. Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.

Authors: Adèle Larcher; Alessio Nocentini; Claudiu T Supuran; Jean-Yves Winum; Arie van der Lee; Jean-Jacques Vasseur; Danielle Laurencin; Michael Smietana
Journal: ACS Med Chem Lett Date: 2019-07-11 Impact factor: 4.345

3. Enhancing fibroblast activation protein (FAP)-targeted radionuclide therapy with albumin binding, and beyond.

Authors: Muhsin H Younis; Sara Malih; Xiaoli Lan; Mohammad Javad Rasaee; Weibo Cai
Journal: Eur J Nucl Med Mol Imaging Date: 2022-05 Impact factor: 10.057

4. Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin α_V β₃.

Authors: André Raposo Moreira Dias; Arianna Pina; Alberto Dal Corso; Daniela Arosio; Laura Belvisi; Luca Pignataro; Michele Caruso; Cesare Gennari
Journal: Chemistry Date: 2017-09-06 Impact factor: 5.236

Review 5. Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity.

Authors: Domenico Marson; Erik Laurini; Suzana Aulic; Maurizio Fermeglia; Sabrina Pricl
Journal: Molecules Date: 2020-02-24 Impact factor: 4.411

Synthetic multivalency for biological applications.

1. Engineering peptide-targeted liposomal nanoparticles optimized for improved selectivity for HER2-positive breast cancer cells to achieve enhanced in vivo efficacy.

2. Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.

3. Enhancing fibroblast activation protein (FAP)-targeted radionuclide therapy with albumin binding, and beyond.

4. Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin α_V β₃.

Review 5. Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity.

Review 6. Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems.

7. Directed Evolution of 2'-Fluoro-Modified, RNA-Supported Carbohydrate Clusters That Bind Tightly to HIV Antibody 2G12.

8. DNA-based control of protein activity.

Review 9. Multivalent nanosystems: targeting monocytes/macrophages.

10. Multivalent Ultrasensitive Interfacing of Supramolecular 1D Nanoplatforms.