Idrissa Diawara1, Khalid Zerouali2, Khalid Katfy3, Bahija Zaki4, Houria Belabbes5, Jillali Najib6, Naima Elmdaghri7. 1. Department of Microbiology, Faculty of Medicine and Pharmacy, 19 rue Tarik Bnou Zyad, Casablanca, Morocco; Bacteriology-Virology and Hospital Hygiene Laboratory, University Hospital Centre Ibn Rochd, 1, Rue des Hôpitaux, Casablanca, Morocco. Electronic address: diawaraidris@gmail.com. 2. Department of Microbiology, Faculty of Medicine and Pharmacy, 19 rue Tarik Bnou Zyad, Casablanca, Morocco; Bacteriology-Virology and Hospital Hygiene Laboratory, University Hospital Centre Ibn Rochd, 1, Rue des Hôpitaux, Casablanca, Morocco. Electronic address: khalid.zerouali2000@gmail.com. 3. Department of Microbiology, Faculty of Medicine and Pharmacy, 19 rue Tarik Bnou Zyad, Casablanca, Morocco; Bacteriology-Virology and Hospital Hygiene Laboratory, University Hospital Centre Ibn Rochd, 1, Rue des Hôpitaux, Casablanca, Morocco. Electronic address: khalidkatfy@hotmail.com. 4. Bacteriology-Virology and Hospital Hygiene Laboratory, University Hospital Centre Ibn Rochd, 1, Rue des Hôpitaux, Casablanca, Morocco. Electronic address: zaki.bahija@yahoo.fr. 5. Department of Microbiology, Faculty of Medicine and Pharmacy, 19 rue Tarik Bnou Zyad, Casablanca, Morocco; Bacteriology-Virology and Hospital Hygiene Laboratory, University Hospital Centre Ibn Rochd, 1, Rue des Hôpitaux, Casablanca, Morocco. Electronic address: belhor2001@yahoo.fr. 6. Department of Pediatric Infectious Diseases and Clinical Immunology, University Hospital Centre Ibn Rochd, Casablanca, Morocco. Electronic address: jilalinajib@hotmail.com. 7. Department of Microbiology, Faculty of Medicine and Pharmacy, 19 rue Tarik Bnou Zyad, Casablanca, Morocco; Bacteriology-Virology and Hospital Hygiene Laboratory, University Hospital Centre Ibn Rochd, 1, Rue des Hôpitaux, Casablanca, Morocco; Pasteur Institute of Morocco, 1 Louis Pasteur place, Casablanca, Morocco. Electronic address: naimaelmdaghri@yahoo.fr.
Abstract
OBJECTIVES: The purpose of this study was to compare the incidence rate of invasive pneumococcal disease, the rates of antibiotic resistance and serotype distribution among children ≤5 years old before and after PCVs introduction in Casablanca, Morocco. METHODS: This study was conducted at the Ibn Rochd University Hospital Centre of Casablanca during two periods encompassing pre-and post-implementation of PCVs, respectively from January 2007 to October 2010 and from January 2011 to December 2014. All the non-duplicate invasive S. pneumoniae isolates recovered during the study periods were included. RESULTS: There were 136 cases of IPD, 91 before and 45 after PCVs introduction. The greatest decrease in incidence rate of IPD occurred in children ≤ 2 years of age declining from 34.6 to 13.5 per 100,000 populations (p<0.0001) before and after vaccination, respectively. The incidence rate of PCV-7, PCV-10 non-PCV-7 and PCV-13 non-PCV-10 serotypes decrease significantly from 18.0 to 4.6, from 5.7 to 1.3 and from 5.7 to 0.8/100,000 population (p<0.001) in the same age, respectively. CONCLUSION: Shifts in the distribution of IPD serotypes and reductions in the incidence rate of disease suggest an effective reduction of the burden of IPD in children, but continued high quality surveillance is critical to assess the changes in serotype distributions.
OBJECTIVES: The purpose of this study was to compare the incidence rate of invasive pneumococcal disease, the rates of antibiotic resistance and serotype distribution among children ≤5 years old before and after PCVs introduction in Casablanca, Morocco. METHODS: This study was conducted at the Ibn Rochd University Hospital Centre of Casablanca during two periods encompassing pre-and post-implementation of PCVs, respectively from January 2007 to October 2010 and from January 2011 to December 2014. All the non-duplicate invasive S. pneumoniae isolates recovered during the study periods were included. RESULTS: There were 136 cases of IPD, 91 before and 45 after PCVs introduction. The greatest decrease in incidence rate of IPD occurred in children ≤ 2 years of age declining from 34.6 to 13.5 per 100,000 populations (p<0.0001) before and after vaccination, respectively. The incidence rate of PCV-7, PCV-10 non-PCV-7 and PCV-13 non-PCV-10 serotypes decrease significantly from 18.0 to 4.6, from 5.7 to 1.3 and from 5.7 to 0.8/100,000 population (p<0.001) in the same age, respectively. CONCLUSION: Shifts in the distribution of IPD serotypes and reductions in the incidence rate of disease suggest an effective reduction of the burden of IPD in children, but continued high quality surveillance is critical to assess the changes in serotype distributions.
Authors: Matt D Wasserman; Heather L Sings; Michele R Wilson; Maarten J Postma; Marie-Claude Breton; Cheryl McDade; Raymond A Farkouh Journal: Infect Dis Ther Date: 2018-11-20
Authors: James Samwel Ngocho; Best Magoma; Gaudencia Alois Olomi; Michael Johnson Mahande; Sia Emmanueli Msuya; Marien Isaäk de Jonge; Blandina Theophil Mmbaga Journal: PLoS One Date: 2019-02-19 Impact factor: 3.240