Literature DB >> 26434299

Structural characterisation and anti-ageing activity of extracellular polysaccharide from a strain of Lachnum sp.

Ming Ye1, Wu-Xi Chen2, Tao Qiu2, Ru-Yue Yuan2, Ying-Wang Ye2, Jing-Min Cai3.   

Abstract

A homogeneous extracellular polysaccharide of Lachnum YM261(LEPS-1) with a molecular weight of 21670Da was characterised. According to HPGPC, IR, periodate oxidation and Smith degradation, GC-MS and (1)H NMR analysis, the results indicated that LEPS-1 was a glucan linked by the β-(1→3)-d-pyran glycosidic bond. The effect of LEPS-1 on anti-ageing in d-gal model mice was also studied. It was found that LEPS-1 significantly increased the activities of antioxidant enzymes (i.e. SOD superoxide dismutase, CAT catalase, GSH-PX glutathione peroxidase) and decreased malondialdehyde (MDA) content in liver, brain and serum of d-gal model mice. These results showed that LEPS-1 had a strong anti-ageing activity.
Copyright © 2011 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anti-ageing activity; Exopolysaccharide; Lachnum; Purification; β-(1→3)-d-Glucan

Mesh：

Substances：

Year:  2011        PMID： 26434299     DOI： 10.1016/j.foodchem.2011.10.087

Source DB:  PubMed          Journal:  Food Chem        ISSN： 0308-8146            Impact factor:   7.514


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