Sophie C Huijskens1, Irma W E M van Dijk2, Rianne de Jong2, Jorrit Visser2, Raquel Dávila Fajardo2, Cécile M Ronckers3, Geert O R J Janssens4, John H Maduro5, Coen R N Rasch2, Tanja Alderliesten2, Arjan Bel2. 1. Academic Medical Center, Department of Radiation Oncology, Amsterdam, The Netherlands. Electronic address: s.c.huijskens@amc.uva.nl. 2. Academic Medical Center, Department of Radiation Oncology, Amsterdam, The Netherlands. 3. Academic Medical Center/Emma Children's Hospital, Department of Pediatric Oncology, Amsterdam, The Netherlands. 4. Radboud University Medical Center, Department of Radiation Oncology, Nijmegen, The Netherlands. 5. University of Groningen, Department of Radiation Oncology, The Netherlands.
Abstract
BACKGROUND AND PURPOSE: To quantify renal and diaphragmatic interfractional motion in order to estimate systematic and random errors, and to investigate the correlation between interfractional motion and patient-specific factors. MATERIAL AND METHODS: We used 527 retrospective abdominal-thoracic cone beam CT scans of 39 childhood cancer patients (<18 years) to quantify renal motion relative to bony anatomy in the left-right (LR), cranio-caudal (CC) and anterior-posterior (AP) directions, and diaphragmatic motion in the CC direction only. Interfractional motion was quantified by distributions of systematic and random errors in each direction (standard deviations Σ and σ, respectively). Also, correlation between organ motion and height was analyzed. RESULTS: Inter-patient organ motion varied widely, with the largest movements in the CC direction. Values of Σ in LR, CC, and AP directions were 1.1, 3.8, 2.1 mm for the right, and 1.3, 3.0, 1.5 mm for the left kidney, respectively. The σ in these three directions was 1.1, 3.1, 1.7 mm for the right, and 1.2, 2.9, 2.1 mm for the left kidney, respectively. For the diaphragm we estimated Σ=5.2 mm and σ=4.0 mm. No correlations were found between organ motion and height. CONCLUSIONS: The large inter-patient organ motion variations and the lack of correlation between motion and patient-related factors, suggest that individualized margin approaches might be required.
BACKGROUND AND PURPOSE: To quantify renal and diaphragmatic interfractional motion in order to estimate systematic and random errors, and to investigate the correlation between interfractional motion and patient-specific factors. MATERIAL AND METHODS: We used 527 retrospective abdominal-thoracic cone beam CT scans of 39 childhood cancerpatients (<18 years) to quantify renal motion relative to bony anatomy in the left-right (LR), cranio-caudal (CC) and anterior-posterior (AP) directions, and diaphragmatic motion in the CC direction only. Interfractional motion was quantified by distributions of systematic and random errors in each direction (standard deviations Σ and σ, respectively). Also, correlation between organ motion and height was analyzed. RESULTS: Inter-patient organ motion varied widely, with the largest movements in the CC direction. Values of Σ in LR, CC, and AP directions were 1.1, 3.8, 2.1 mm for the right, and 1.3, 3.0, 1.5 mm for the left kidney, respectively. The σ in these three directions was 1.1, 3.1, 1.7 mm for the right, and 1.2, 2.9, 2.1 mm for the left kidney, respectively. For the diaphragm we estimated Σ=5.2 mm and σ=4.0 mm. No correlations were found between organ motion and height. CONCLUSIONS: The large inter-patient organ motion variations and the lack of correlation between motion and patient-related factors, suggest that individualized margin approaches might be required.
Authors: Jinsoo Uh; Matthew J Krasin; Yimei Li; Xingyu Li; Christopher Tinkle; John T Lucas; Thomas E Merchant; Chiaho Hua Journal: Int J Radiat Oncol Biol Phys Date: 2017-05-25 Impact factor: 8.013
Authors: Sophie C Huijskens; Irma W E M van Dijk; Jorrit Visser; Brian V Balgobind; D Te Lindert; Coen R N Rasch; Tanja Alderliesten; Arjan Bel Journal: Radiat Oncol Date: 2018-09-12 Impact factor: 3.481