Chiho Muranushi1, Catherine M Olsen2, Adèle C Green3, Nirmala Pandeya4. 1. School of Population Health, The University of Queensland, Brisbane, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Australia. Electronic address: chiho.muranushi@uqconnect.edu.au. 2. QIMR Berghofer Medical Research Institute, Brisbane, Australia. 3. QIMR Berghofer Medical Research Institute, Brisbane, Australia; CRUK Manchester Institute and Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom. 4. School of Population Health, The University of Queensland, Brisbane, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Abstract
BACKGROUND: Evidence for an association between aspirin or other nonsteroidal antiinflammatory drug (NSAID) use and basal cell carcinoma (BCC) has been inconsistent. OBJECTIVE: We conducted a systematic review and metaanalysis to assess the effect of oral NSAIDs on BCC. METHODS: PubMed, Web of Science, and Embase databases were searched up to December 3, 2014. A random effects model metaanalysis was used to calculate summary estimates of the effects of aspirin, nonaspirin NSAIDs, or any (aspirin or nonaspirin) NSAID use in patients with BCC. RESULTS: The summary estimates from 11 studies (1 randomized controlled trial, 5 cohort studies, and 5 case control studies) found a 10% risk reduction of BCC among those using any NSAID (relative risk [RR], 0.90 [95% confidence interval {CI}, 0.84-0.97]). A similar but not statistically significant inverse association was observed for nonaspirin NSAIDs (RR, 0.93 [95% CI, 0.86-1.02]), while aspirin use was more weakly associated (RR, 0.95 [95% CI, 0.91-1.00]). The strongest inverse associations were noted among those with either a history of skin cancers or a high prevalence of actinic keratoses. LIMITATIONS: Dose-effect estimates could not be calculated because the available data were too heterogeneous to pool. CONCLUSION: The intake of NSAIDs may help prevent BCC, particularly in high-risk populations. A large randomized controlled trial is required to confirm these findings.
BACKGROUND: Evidence for an association between aspirin or other nonsteroidal antiinflammatory drug (NSAID) use and basal cell carcinoma (BCC) has been inconsistent. OBJECTIVE: We conducted a systematic review and metaanalysis to assess the effect of oral NSAIDs on BCC. METHODS: PubMed, Web of Science, and Embase databases were searched up to December 3, 2014. A random effects model metaanalysis was used to calculate summary estimates of the effects of aspirin, nonaspirin NSAIDs, or any (aspirin or nonaspirin) NSAID use in patients with BCC. RESULTS: The summary estimates from 11 studies (1 randomized controlled trial, 5 cohort studies, and 5 case control studies) found a 10% risk reduction of BCC among those using any NSAID (relative risk [RR], 0.90 [95% confidence interval {CI}, 0.84-0.97]). A similar but not statistically significant inverse association was observed for nonaspirin NSAIDs (RR, 0.93 [95% CI, 0.86-1.02]), while aspirin use was more weakly associated (RR, 0.95 [95% CI, 0.91-1.00]). The strongest inverse associations were noted among those with either a history of skin cancers or a high prevalence of actinic keratoses. LIMITATIONS: Dose-effect estimates could not be calculated because the available data were too heterogeneous to pool. CONCLUSION: The intake of NSAIDs may help prevent BCC, particularly in high-risk populations. A large randomized controlled trial is required to confirm these findings.
Authors: M N Passarelli; E L Barry; D Zhang; P Gangar; J R Rees; R S Bresalier; G McKeown-Eyssen; M R Karagas; J A Baron Journal: Br J Dermatol Date: 2018-06-19 Impact factor: 9.302
Authors: Mabel K Yan; Suzanne G Orchard; Nikki R Adler; Rory Wolfe; Catriona McLean; Luz María Rodriguez; Robyn L Woods; Peter Gibbs; Andrew T Chan; Andrew Haydon; Victoria J Mar Journal: Cancer Prev Res (Phila) Date: 2022-06-02