| Literature DB >> 26431839 |
Fabricia Petronilho1, Drielly Florentino2, Lucinéia Gainski Danielski2, Luiz Carlos Vieira2, Maryane Modolon Martins2, Andriele Vieira2, Sandra Bonfante2, Mariana Pereira Goldim2, Francieli Vuolo3.
Abstract
Sepsis progression is linked with the imbalance between reactive oxygen species and antioxidant enzymes. Thus, the aim of this study was to evaluate the effect of alpha-lipoic acid (ALA), a powerful antioxidant, in organs of rats submitted to sepsis. Male Wistar rats were subjected to sepsis by cecal ligation puncture (CLP) and treated with ALA or vehicle. After CLP (12 and 24 h), the myeloperoxidase (MPO) activity, protein and lipid oxidative damage, and antioxidant enzymes in the liver, kidney, heart, and lung were evaluated. ALA was effective in reducing MPO activity, lipid peroxidation in the liver, and protein carbonylation only in the kidney in 12 h after CLP. In 12 h, SOD activity increased in the kidney and CAT activity in the liver and kidney with ALA treatment. Thus, ALA was able to reduce the inflammation and oxidative stress in the liver and kidney after sepsis in rats.Entities:
Keywords: alpha-lipoic acid; organ failure; oxidative damage; sepsis
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Year: 2016 PMID： 26431839 DOI： 10.1007/s10753-015-0256-4
Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092