Mert İlhan1, Ismail Eser Bolat2, İpek Süntar1, Harika Kutluay Köklü3, Dilek A Uğar Çankal3, Hikmet Keleş4, Esra Küpeli Akkol5. 1. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey. 2. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey. 3. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey. 4. Department of Pathology, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200 Afyonkarahisar, Turkey. 5. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey. Electronic address: esrak@gazi.edu.tr.
Abstract
OBJECTIVE: In Turkish folk medicine Momordica charantia L. is used for wound healing. The aim of the present study is to investigate this folkloric knowledge and confirm the plant's potential effect on buccal mucosa wound in the rat. DESIGN: Wound healing activity of olive oil macerate of Momordica charantia L. was investigated in linear incision and circular excision wound models created in the buccal mucosa of the rat. The tissues were histopathologically evaluated, moreover, hydroxyproline contents of the tissues were determined. The anti-inflammatory activity was also assessed by using Whittle method with some modifications. RESULTS: Olive oil macerate of M. charantia showed significant wound healing activity both in incision (45.1%) and excision (89.8%) wound models and demonstrated anti-inflammatory activity with the inhibition value of 31.3% at the dose of 100mg/kg. CONCLUSION: The experimental data revealed that M. charantia showed significant wound healing and anti-inflammatory effect.
OBJECTIVE: In Turkish folk medicine Momordica charantia L. is used for wound healing. The aim of the present study is to investigate this folkloric knowledge and confirm the plant's potential effect on buccal mucosa wound in the rat. DESIGN: Wound healing activity of olive oil macerate of Momordica charantia L. was investigated in linear incision and circular excision wound models created in the buccal mucosa of the rat. The tissues were histopathologically evaluated, moreover, hydroxyproline contents of the tissues were determined. The anti-inflammatory activity was also assessed by using Whittle method with some modifications. RESULTS:Olive oil macerate of M. charantia showed significant wound healing activity both in incision (45.1%) and excision (89.8%) wound models and demonstrated anti-inflammatory activity with the inhibition value of 31.3% at the dose of 100mg/kg. CONCLUSION: The experimental data revealed that M. charantia showed significant wound healing and anti-inflammatory effect.
Authors: William Antonio Sagástegui-Guarniz; Carmen R Silva-Correa; Víctor E Villarreal-La Torre; María V González-Blas; Walter O Sagástegui-Guarniz; Abhel A Calderón-Peña; Cinthya L Aspajo-Villalaz; José L Cruzado-Razco; Julio Hilario-Vargas Journal: Vet World Date: 2021-10-22