Eva K Fenwick1, Jing Xie2, Ryan Eyn Kidd Man3, Lyndell L Lim2, Victoria M Flood4, Robert P Finger2, Tien Y Wong5, Ecosse L Lamoureux5. 1. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Australia. Electronic address: fenwicke@unimelb.edu.au. 2. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Australia. 3. Singapore Eye Research Institute, National University of Singapore, Singapore. 4. Faculty of Health Sciences, University of Sydney, Australia and St Vincent's Hospital, Sydney, Australia. 5. Singapore Eye Research Institute, National University of Singapore, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore.
Abstract
AIM: To explore the association between alcohol consumption and the severity of diabetic retinopathy (DR). METHODS: In this cross-sectional study, patients with type 2 diabetes answered questions on consumption of low and full-strength beer, white wine/champagne, red wine, fortified wines, and spirits. Never, moderate and high consumption of each alcoholic beverage, and overall alcoholic beverage consumption, were defined as <1, 1-14 and >14 standard drinks/week, respectively. DR was categorized into none; non vision-threatening DR (VTDR) and VTDR. Multivariable logistic regression determined the associations between alcohol consumption and DR. RESULTS: Of the 395 participants (mean age±SD [standard deviation] 65.9±10.4years; males=253), 188 (47.6%) consumed alcohol and 235 (59.5%) had any DR. Compared to no alcohol consumption, moderate alcohol consumption (overall) was significantly associated with reduced odds of any DR (OR=0.47, 95% CI [confidence interval] 0.26-0.85). Moderate consumption of white wine/champagne or fortified wine was also associated with reduced odds of any DR (OR=0.48, 95% CI 0.25-0.91, and OR=0.15, 95% CI 0.04-0.62, respectively). Similar results were observed for non-VTDR and VTDR. CONCLUSIONS: The amount and type of alcohol are associated with risk of DR in patients with type 2 diabetes. A longitudinal study is needed to assess the protective effect of alcohol consumption and DR.
AIM: To explore the association between alcohol consumption and the severity of diabetic retinopathy (DR). METHODS: In this cross-sectional study, patients with type 2 diabetes answered questions on consumption of low and full-strength beer, white wine/champagne, red wine, fortified wines, and spirits. Never, moderate and high consumption of each alcoholic beverage, and overall alcoholic beverage consumption, were defined as <1, 1-14 and >14 standard drinks/week, respectively. DR was categorized into none; non vision-threatening DR (VTDR) and VTDR. Multivariable logistic regression determined the associations between alcohol consumption and DR. RESULTS: Of the 395 participants (mean age±SD [standard deviation] 65.9±10.4years; males=253), 188 (47.6%) consumed alcohol and 235 (59.5%) had any DR. Compared to no alcohol consumption, moderate alcohol consumption (overall) was significantly associated with reduced odds of any DR (OR=0.47, 95% CI [confidence interval] 0.26-0.85). Moderate consumption of white wine/champagne or fortified wine was also associated with reduced odds of any DR (OR=0.48, 95% CI 0.25-0.91, and OR=0.15, 95% CI 0.04-0.62, respectively). Similar results were observed for non-VTDR and VTDR. CONCLUSIONS: The amount and type of alcohol are associated with risk of DR in patients with type 2 diabetes. A longitudinal study is needed to assess the protective effect of alcohol consumption and DR.
Authors: Mark Y Z Wong; Ryan E K Man; Eva K Fenwick; Preeti Gupta; Ling-Jun Li; Rob M van Dam; Mary F Chong; Ecosse L Lamoureux Journal: PLoS One Date: 2018-01-11 Impact factor: 3.240
Authors: Ricardo Raúl Robles-Rivera; José Alberto Castellanos-González; Cecilia Olvera-Montaño; Raúl Alonso Flores-Martin; Ana Karen López-Contreras; Diana Esperanza Arevalo-Simental; Ernesto Germán Cardona-Muñoz; Luis Miguel Roman-Pintos; Adolfo Daniel Rodríguez-Carrizalez Journal: Oxid Med Cell Longev Date: 2020-03-11 Impact factor: 6.543