Literature DB >> 26429911

Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells.

Xuerui Luo1, Jia Nie1, Shuaiwei Wang1, Zuojia Chen1, WanJun Chen2, Dan Li1, Hui Hu3, Bin Li4.   

Abstract

Poly(ADP-ribose) polymerase 1 (PARP-1) is an ADP-ribosylating enzyme participating in diverse cellular functions. The roles of PARP-1 in the immune system, however, have not been well understood. Here we find that PARP-1 interacts with FOXP3 and induces its poly(ADP-ribosyl)ation. By using PARP-1 inhibitors, we show that reduced poly(ADP-ribosyl)ation of FOXP3 results in not only FOXP3 stabilization and increased FOXP3 downstream genes but also enhanced suppressive function of regulatory T cells. Our results suggest that PARP-1 negatively regulates the suppressive function of Treg cells at the posttranslational level via FOXP3 poly(ADP-ribosyl)ation. This finding has implications for developing PARP-1 inhibitors as potential agents for the prevention and treatment of autoimmune diseases.
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  ADP-ribosylation; T cell; forkhead box P3 (FOXP3); immunosuppression; inhibitor; posttranscriptional regulation; regulatory T cell

Mesh：

Substances：

Year:  2015        PMID： 26429911      PMCID： PMC4661383          DOI： 10.1074/jbc.M115.661611

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  25 in total

1.  NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1.

Authors:  Mi Young Kim; Steven Mauro; Nicolas Gévry; John T Lis; W Lee Kraus
Journal:  Cell       Date:  2004-12-17       Impact factor: 41.582

Review 2.  Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.

Authors:  D D'Amours; S Desnoyers; I D'Silva; G G Poirier
Journal:  Biochem J       Date:  1999-09-01       Impact factor: 3.857

3.  Role of ADP-ribosylation in activated monocytes/macrophages.

Authors:  S Hauschildt; P Scheipers; W Bessler; K Schwarz; A Ullmer; H D Flad; H Heine
Journal:  Adv Exp Med Biol       Date:  1997       Impact factor: 2.622

4.  The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis.

Authors:  A Ruf; V Rolli; G de Murcia; G E Schulz
Journal:  J Mol Biol       Date:  1998-04-24       Impact factor: 5.469

5.  Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.

Authors:  M E Brunkow; E W Jeffery; K A Hjerrild; B Paeper; L B Clark; S A Yasayko; J E Wilkinson; D Galas; S F Ziegler; F Ramsdell
Journal:  Nat Genet       Date:  2001-01       Impact factor: 38.330

6.  Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase.

Authors:  J G Mabley; P Jagtap; M Perretti; S J Getting; A L Salzman; L Virág; E Szabó; F G Soriano; L Liaudet; G E Abdelkarim; G Haskó; A Marton; G J Southan; C Szabó
Journal:  Inflamm Res       Date:  2001-11       Impact factor: 4.575

7.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.

Authors:  Jason D Fontenot; Marc A Gavin; Alexander Y Rudensky
Journal:  Nat Immunol       Date:  2003-03-03       Impact factor: 25.606

Review 8.  The PARP superfamily.

Authors:  Jean-Christophe Amé; Catherine Spenlehauer; Gilbert de Murcia
Journal:  Bioessays       Date:  2004-08       Impact factor: 4.345

9.  High resolution fractionation and characterization of ADP-ribose polymers.

Authors:  C C Kiehlbauch; N Aboul-Ela; E L Jacobson; D P Ringer; M K Jacobson
Journal:  Anal Biochem       Date:  1993-01       Impact factor: 3.365

Review 10.  PARP goes transcription.

Authors:  W Lee Kraus; John T Lis
Journal:  Cell       Date:  2003-06-13       Impact factor: 41.582
View more
  23 in total

1.  Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice.

Authors:  Lucia Moreno-Lama; Miguel A Galindo-Campos; Carlos Martínez; Laura Comerma; Ivonne Vazquez; María Vernet-Tomas; Coral Ampurdanés; Nura Lutfi; Juan Martin-Caballero; Françoise Dantzer; Miguel Quintela-Fandino; Syed O Ali; Jaime Jimeno; José Yélamos
Journal:  Oncogene       Date:  2020-01-30       Impact factor: 9.867

2.  Metabolic Choice Tunes Foxp3+ Regulatory T Cell Function.

Authors:  Xiaoxia Wang; Hao Cheng; Yige Shen; Bin Li
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

3.  The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis.

Authors:  Akbar Ahmad; Juliana de Camargo Vieira; Aline Haas de Mello; Thais Martins de Lima; Suely Kubo Ariga; Denise Frediani Barbeiro; Hermes Vieira Barbeiro; Bartosz Szczesny; Gábor Törö; Nadiya Druzhyna; Elisa B Randi; Michela Marcatti; Tracy Toliver-Kinsky; András Kiss; Lucas Liaudet; Reinaldo Salomao; Francisco Garcia Soriano; Csaba Szabo
Journal:  Pharmacol Res       Date:  2019-05-06       Impact factor: 7.658

4.  c-Abl-Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes.

Authors:  Ameer Ali Bohio; Aman Sattout; Ruoxi Wang; Ke Wang; Rajiv Kumar Sah; Xiaolan Guo; Xianlu Zeng; Yueshuang Ke; Istvan Boldogh; Xueqing Ba
Journal:  J Immunol       Date:  2019-08-09       Impact factor: 5.422

5.  Cartilage oligomeric matrix protein is a prognostic factor and biomarker of colon cancer and promotes cell proliferation by activating the Akt pathway.

Authors:  Ting-Ting Liu; Xi-Sheng Liu; Meng Zhang; Xue-Ni Liu; Fu-Xiang Zhu; Fang-Ming Zhu; Si-Wen Ouyang; Shan-Bao Li; Chen-Long Song; Hui-Min Sun; Su Lu; Yu Zhang; Jun Lin; Hua-Mei Tang; Zhi-Hai Peng
Journal:  J Cancer Res Clin Oncol       Date:  2018-03-20       Impact factor: 4.553

Review 6.  Understanding specific functions of PARP-2: new lessons for cancer therapy.

Authors:  Syed O Ali; Farhaan A Khan; Miguel A Galindo-Campos; José Yélamos
Journal:  Am J Cancer Res       Date:  2016-09-01       Impact factor: 6.166

7.  First-Line PARP Inhibitors-Emerging Side Effects Require Caution: A Case of PARPi-Induced Pneumonitis.

Authors:  Alistair McLaren; Douglas Cartwright; Ewen Ross; Patricia Roxburgh
Journal:  J Immunother Precis Oncol       Date:  2021-04-15

8.  PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy.

Authors:  Qian Li; Zhuo-Ming Li; Shu-Ya Sun; Lu-Ping Wang; Pan-Xia Wang; Zhen Guo; Han-Wei Yang; Jian-Tao Ye; Jing Lu; Pei-Qing Liu
Journal:  Acta Pharmacol Sin       Date:  2018-07-20       Impact factor: 6.150

9.  Ring finger protein 31-mediated atypical ubiquitination stabilizes forkhead box P3 and thereby stimulates regulatory T-cell function.

Authors:  Fuxiang Zhu; Gang Yi; Xu Liu; Fangming Zhu; Anna Zhao; Aiting Wang; Ruihong Zhu; Zuojia Chen; Binbin Zhao; Sijie Fang; Xiao Yu; Ruirong Lin; Rui Liang; Dan Li; Wenyi Zhao; Zizhen Zhang; Wenzhi Guo; Shuijun Zhang; Shengfang Ge; Xianqun Fan; Gang Zhao; Bin Li
Journal:  J Biol Chem       Date:  2018-11-02       Impact factor: 5.157

Review 10.  Regulatory T cells in ischemic stroke.

Authors:  Huan Wang; Zhao Wang; Qianqian Wu; Yujia Yuan; Wen Cao; Xiangjian Zhang
Journal:  CNS Neurosci Ther       Date:  2021-01-20       Impact factor: 5.243
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.