| Literature DB >> 26429627 |
Abstract
What are the minimum specificity requirements of a thymic selective process that establishes (1) restrictive recognition of peptide, (2) the Self (S)-Nonself (NS) discrimination, and (3) the categories of effector function? Given an answer to that question, how well does it fit with the observed selective processes in thymus where T-cells are generated? Any discrepancies between the two must be rationalized. The goal of this essay is to attempt just that.Keywords: Cytotoxic T-cells; Peripheralized T-cells; T-helpers; T-suppressors; Thymic negative selection; Thymic positive selection
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Year: 2015 PMID： 26429627 DOI： 10.1016/j.cellimm.2015.09.008
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868