Mario Rodrigues Melo Filho1, Luis Antônio Nogueira dos Santos2, Daniella Reis Barbosa Martelli2, Marise Fagundes Silveira3, Myrian Esteves da Silva4, Letízia Monteiro de Barros5, Ricardo D Coletta6, Hercílio Martelli-Júnior7. 1. Professor Full of Dental School, University of Montes Claros, Montes Claros, Minas Gerais, Brazil. Electronic address: mariomelo@gmail.com. 2. Professor Full of Dental School, University of Montes Claros, Montes Claros, Minas Gerais, Brazil. 3. Professor Associate of Math School, University of Montes Claros, Av Rui Braga - Vila Mauriceia - Campus Darcy Ribeiro - CEP 39401-089, Montes Claros, Minas Gerais, Brazil. 4. Dentist of the Center for Rehabilitation of Craniofacial Anomalies, Dental School, University of José Rosário Vellano, Minas Gerais, Brazil. 5. Professor Associate of the Center for Rehabilitation of Craniofacial Anomalies, Dental School, University of José Rosário Vellano, Minas Gerais, Brazil. 6. Professor Associate of the Department of Oral Diagnosis, School of Dentistry, State University of Campinas, São Paulo, Brazil. 7. Professor Full of Dental School, University of Montes Claros, Montes Claros, Minas Gerais, Brazil; Professor Associate of the Center for Rehabilitation of Craniofacial Anomalies, Dental School, University of José Rosário Vellano, Minas Gerais, Brazil.
Abstract
OBJECTIVES: The purpose of this study was to evaluate the prevalence of taurodontism in patients with nonsyndromic cleft lip and palate (NSCLP) within a Brazilian population. STUDY DESIGN: The study was designed as an epidemiologic case-control single-center study. Three hundred eighty-eight patients were included: 88 had NSCLP, and 300 comprised the control group. The first and second permanent mandibular molars were included in this study. By using panoramic radiographs, taurodontism was categorized as mesotaurodontism, hypotaurodontism, and hypertaurodontism. RESULTS: Seventy patients (23.3%) from the control group and 36 patients (40.9%) from the case group presented taurodontism (P < .001). In the control group, 108 (9%) teeth showed taurodontism, whereas in the case group with cleft lip and palate (CLP), 64 (18.2%) teeth showed dental anomalies (P < .001). In both groups, most taurodontic teeth presented hypotaurodontism, followed by mesotaurodontism, while hypertaurodontism was found in only two teeth. The probability of taurodontism in patients with cleft lip (CL) was 2.36 (P = .010) times higher compared with those with CLP, whereas the occurrence of taurodontism in patients with cleft palate (CP) was 3.15 (P = .002) times greater than in patients with CLP. CONCLUSIONS: The results from this study indicate a close relationship between taurodontism and NSCLP and the possibility of different cleft subphenotypes.
OBJECTIVES: The purpose of this study was to evaluate the prevalence of taurodontism in patients with nonsyndromic cleft lip and palate (NSCLP) within a Brazilian population. STUDY DESIGN: The study was designed as an epidemiologic case-control single-center study. Three hundred eighty-eight patients were included: 88 had NSCLP, and 300 comprised the control group. The first and second permanent mandibular molars were included in this study. By using panoramic radiographs, taurodontism was categorized as mesotaurodontism, hypotaurodontism, and hypertaurodontism. RESULTS: Seventy patients (23.3%) from the control group and 36 patients (40.9%) from the case group presented taurodontism (P < .001). In the control group, 108 (9%) teeth showed taurodontism, whereas in the case group with cleft lip and palate (CLP), 64 (18.2%) teeth showed dental anomalies (P < .001). In both groups, most taurodontic teeth presented hypotaurodontism, followed by mesotaurodontism, while hypertaurodontism was found in only two teeth. The probability of taurodontism in patients with cleft lip (CL) was 2.36 (P = .010) times higher compared with those with CLP, whereas the occurrence of taurodontism in patients with cleft palate (CP) was 3.15 (P = .002) times greater than in patients with CLP. CONCLUSIONS: The results from this study indicate a close relationship between taurodontism and NSCLP and the possibility of different cleft subphenotypes.
Authors: Sooji Choi; Janice S Lee; Carol W Bassim; Harvey Kushner; Ann G Carr; Pamela J Gardner; Laura A Harney; Kris Ann P Schultz; Douglas R Stewart Journal: Am J Med Genet A Date: 2019-07-16 Impact factor: 2.802