Kazuto Suda1, Hiroyuki Koga2, Manabu Okawada1, Takashi Doi1, Go Miyano1, Geoffrey J Lane1, Atsuyuki Yamataka1. 1. Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, Japan. 2. Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: h-koga@juntendo.ac.jp.
Abstract
PURPOSE: We reviewed renal function after pyeloplasty (PP) in cases of prenatally diagnosed ureteropelvic junction obstruction (PDUPJO) to determine the impact of preoperative urinary tract infection (UTI) on the timing of PP. METHODS: We retrospectively reviewed 81 cases of PDUPJO diagnosed between 1998 and 2013. Incidence of UTI was used to divide 37 kidneys requiring PP (3 bilateral) into U(-): UTI≤1; n=25, and U(+): UTI≥2; n=12 to compare age at PP, grade of hydronephrosis (HN) on ultrasonography (US), glomerular filtration rate (GFR) on diethylenetriaminepentacetic acid (DTPA) renography, and uptake on dimercaptosuccinic acid (DMSA) scintigraphy pre/post PP. RESULTS: Age at first UTI and age at PP were similar. HN improved significantly postPP in all cases. Although DTPA and DMSA were similar prePP, improvement postPP was better in U(-) than U(+), but only DMSA in U(-) was statistically significant (15.2%±4.0% vs. 20%±3.7%; p=0.049). There were no complications or UTI postPP. CONCLUSION: Two or more UTIs would appear to be associated with postPP renal dysfunction in PDUPJO. Thus, PP should be performed after the initial UTI but before the second UTI.
PURPOSE: We reviewed renal function after pyeloplasty (PP) in cases of prenatally diagnosed ureteropelvic junction obstruction (PDUPJO) to determine the impact of preoperative urinary tract infection (UTI) on the timing of PP. METHODS: We retrospectively reviewed 81 cases of PDUPJO diagnosed between 1998 and 2013. Incidence of UTI was used to divide 37 kidneys requiring PP (3 bilateral) into U(-): UTI≤1; n=25, and U(+): UTI≥2; n=12 to compare age at PP, grade of hydronephrosis (HN) on ultrasonography (US), glomerular filtration rate (GFR) on diethylenetriaminepentacetic acid (DTPA) renography, and uptake on dimercaptosuccinic acid (DMSA) scintigraphy pre/post PP. RESULTS: Age at first UTI and age at PP were similar. HN improved significantly postPP in all cases. Although DTPA and DMSA were similar prePP, improvement postPP was better in U(-) than U(+), but only DMSA in U(-) was statistically significant (15.2%±4.0% vs. 20%±3.7%; p=0.049). There were no complications or UTI postPP. CONCLUSION: Two or more UTIs would appear to be associated with postPPrenal dysfunction in PDUPJO. Thus, PP should be performed after the initial UTI but before the second UTI.