Literature DB >> 26427567

What is the Contribution of Genetics to Periodontal Risk?

Bruno G Loos1, Georgios Papantonopoulos2, Søren Jepsen3, Marja L Laine4.   

Abstract

This review addresses the multicausal etiology of periodontitis, in which genetic factors play a role. The various proposed causes for periodontitis always work simultaneously, but the relative contribution of each of these varies from case to case. We are still at an early stage to identify the genes involved, in comparison with other chronic diseases. To date, the genetic variations firmly and repeatedly associated with periodontitis in some populations are found within the following genes: ANRIL, COX2, IL1, IL10, DEFB1, whereas many other proposed periodontitis candidate genes have not been firmly proven or replicated.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Candidate gene; Complex disease; Etiology; GWAS; Genetics; Multi-causality; Periodontitis

Mesh：

Year:  2015        PMID： 26427567     DOI： 10.1016/j.cden.2015.06.005

Source DB:  PubMed          Journal:  Dent Clin North Am        ISSN： 0011-8532


  30 in total

1.  What Is the Heritability of Periodontitis? A Systematic Review.

Authors:  L Nibali; J Bayliss-Chapman; S A Almofareh; Y Zhou; K Divaris; A R Vieira
Journal:  J Dent Res       Date:  2019-06       Impact factor: 6.116

2.  Microbiome Profiles of Ligature-Induced Periodontitis in Nonhuman Primates across the Life Span.

Authors:  Sreenatha Kirakodu; Jin Chen; Janis Gonzalez Martinez; Octavio A Gonzalez; Jeffrey Ebersole
Journal:  Infect Immun       Date:  2019-05-21       Impact factor: 3.441

3.  Protocols, Methods, and Tools for Genome-Wide Association Studies (GWAS) of Dental Traits.

Authors:  Cary S Agler; Dmitry Shungin; Andrea G Ferreira Zandoná; Paige Schmadeke; Patricia V Basta; Jason Luo; John Cantrell; Thomas D Pahel; Beau D Meyer; John R Shaffer; Arne S Schaefer; Kari E North; Kimon Divaris
Journal:  Methods Mol Biol       Date:  2019

4.  Dysregulation of human miRNAs and increased prevalence of HHV miRNAs in obese periodontitis subjects.

Authors:  Afsar R Naqvi; Maria F Brambila; Gloria Martínez; Gabriela Chapa; Salvador Nares
Journal:  J Clin Periodontol       Date:  2019-01       Impact factor: 8.728

5.  Fetal Weight Outcomes in C57BL/6J and C57BL/6NCrl Mice after Oral Colonization with Porphyromonas gingivalis.

Authors:  Lori A Fischer; Peter D Bittner-Eddy; Massimo Costalonga
Journal:  Infect Immun       Date:  2019-09-19       Impact factor: 3.441

Review 6.  Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1.

Authors:  Maria G Balta; Bruno G Loos; Elena A Nicu
Journal:  Front Immunol       Date:  2017-12-14       Impact factor: 7.561

Review 7.  Genes Critical for Developing Periodontitis: Lessons from Mouse Models.

Authors:  Teun J de Vries; Stefano Andreotta; Bruno G Loos; Elena A Nicu
Journal:  Front Immunol       Date:  2017-10-27       Impact factor: 7.561

Review 8.  The role of inflammation and genetics in periodontal disease.

Authors:  Bruno G Loos; Thomas E Van Dyke
Journal:  Periodontol 2000       Date:  2020-06       Impact factor: 7.589

9.  Interleukin 1β (+3954; -511) Genotype Polymorphism and its Association with Severe Chronic Generalized Periodontitis in the Malaysian Population.

Authors:  Shelly Arora; Srinivas Sulugodu Ramachandra; Fawzia Abdullah; Kalyan C Gundavarapu
Journal:  Contemp Clin Dent       Date:  2017 Jan-Mar

10.  Chronic Exposure of Gingival Fibroblasts to TLR2 or TLR4 Agonist Inhibits Osteoclastogenesis but Does Not Affect Osteogenesis.

Authors:  Gerasimos D Karlis; Emily Schöningh; Ineke D C Jansen; Ton Schoenmaker; Jolanda M A Hogervorst; Henk A van Veen; Carolyn G J Moonen; Katarzyna B Łagosz-Ćwik; Tim Forouzanfar; Teun J de Vries
Journal:  Front Immunol       Date:  2020-07-23       Impact factor: 7.561
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