Literature DB >> 26427449

Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa.

David A Parfitt1, Michael E Cheetham2.   

Abstract

Mutations in rhodopsin are one of the most common causes of retinitis pigmentosa (RP). Misfolding of rhodopsin can result in disruptions in cellular protein homeostasis, or proteostasis. There is currently no available treatment for RP. In this review, we discuss the different approaches currently being investigated for treatment of rhodopsin RP, focusing on the potential of manipulation of the proteostasis network as a therapeutic approach to combat retinal degeneration.

Entities:  

Keywords:  ERAD; Heat shock proteins; Molecular chaperones; P23H; Proteostasis; Retinal degeneration; Retinitis pigmentosa; Rhodopsin

Mesh：

Substances：

Year:  2016        PMID： 26427449      PMCID： PMC5042317          DOI： 10.1007/978-3-319-17121-0_64

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  29 in total

1.  IRE1 signaling affects cell fate during the unfolded protein response.

Authors:  Jonathan H Lin; Han Li; Douglas Yasumura; Hannah R Cohen; Chao Zhang; Barbara Panning; Kevan M Shokat; Matthew M Lavail; Peter Walter
Journal:  Science       Date:  2007-11-09       Impact factor: 47.728

Review 2.  Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.

Authors:  R I Morimoto
Journal:  Genes Dev       Date:  1998-12-15       Impact factor: 11.361

Review 3.  Protein sorting, targeting and trafficking in photoreceptor cells.

Authors:  Jillian N Pearring; Raquel Y Salinas; Sheila A Baker; Vadim Y Arshavsky
Journal:  Prog Retin Eye Res       Date:  2013-04-03       Impact factor: 21.198

4.  Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa.

Authors:  T P Dryja; T L McGee; L B Hahn; G S Cowley; J E Olsson; E Reichel; M A Sandberg; E L Berson
Journal:  N Engl J Med       Date:  1990-11-08       Impact factor: 91.245

5.  Retinitis pigmentosa mutants provide insight into the role of the N-terminal cap in rhodopsin folding, structure, and function.

Authors:  Chikwado A Opefi; Kieron South; Christopher A Reynolds; Steven O Smith; Philip J Reeves
Journal:  J Biol Chem       Date:  2013-10-08       Impact factor: 5.157

6.  The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation.

Authors:  Richard S Saliba; Peter M G Munro; Philip J Luthert; Michael E Cheetham
Journal:  J Cell Sci       Date:  2002-07-15       Impact factor: 5.285

7.  BiP prevents rod opsin aggregation.

Authors:  Dimitra Athanasiou; Maria Kosmaoglou; Naheed Kanuga; Sergey S Novoselov; Adrienne W Paton; James C Paton; J Paul Chapple; Michael E Cheetham
Journal:  Mol Biol Cell       Date:  2012-08-01       Impact factor: 4.138

Review 8.  Molecular chaperones and photoreceptor function.

Authors:  Maria Kosmaoglou; Nele Schwarz; John S Bett; Michael E Cheetham
Journal:  Prog Retin Eye Res       Date:  2008-03-29       Impact factor: 21.198

9.  Hsp90 inhibition protects against inherited retinal degeneration.

Authors:  Mònica Aguilà; Dalila Bevilacqua; Caroline McCulley; Nele Schwarz; Dimitra Athanasiou; Naheed Kanuga; Sergey S Novoselov; Clemens A K Lange; Robin R Ali; James W Bainbridge; Carlos Gias; Peter J Coffey; Pere Garriga; Michael E Cheetham
Journal:  Hum Mol Genet       Date:  2013-12-02       Impact factor: 6.150

10.  The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control.

Authors:  Dimitra Athanasiou; Dalila Bevilacqua; Monica Aguila; Caroline McCulley; Naheed Kanuga; Takao Iwawaki; J Paul Chapple; Michael E Cheetham
Journal:  Hum Mol Genet       Date:  2014-07-23       Impact factor: 6.150
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  5 in total

1.  Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides.

Authors:  Irene Vázquez-Domínguez; Alejandro Garanto
Journal:  Methods Mol Biol       Date:  2022

2.  Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis.

Authors:  Justin T Marinko; Hui Huang; Wesley D Penn; John A Capra; Jonathan P Schlebach; Charles R Sanders
Journal:  Chem Rev       Date:  2019-01-04       Impact factor: 60.622

3.  Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice.

Authors:  Aiden Eblimit; Smriti Akshay Agrawal; Kandace Thomas; Ivan Assenov Anastassov; Tajiguli Abulikemu; Yalda Moayedi; Graeme Mardon; Rui Chen
Journal:  Exp Eye Res       Date:  2017-10-31       Impact factor: 3.467

Review 4.  Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal.

Authors:  Bin Fan; Ying-Jian Sun; Shu-Yan Liu; Lin Che; Guang-Yu Li
Journal:  Int J Mol Sci       Date:  2017-01-19       Impact factor: 5.923

Review 5.  Molecular Therapies for Inherited Retinal Diseases-Current Standing, Opportunities and Challenges.

Authors:  Irene Vázquez-Domínguez; Alejandro Garanto; Rob W J Collin
Journal:  Genes (Basel)       Date:  2019-08-28       Impact factor: 4.096
  5 in total

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