Literature DB >> 26426434

Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants.

Venkatesh Sampath1, Daniel Helbling, Heather Menden, David Dimmock, Neil P Mulrooney, Jeffrey C Murray, John M Dagle, Jeffery S Garland.   

Abstract

Reactive oxygen species mediate intestinal injury in necrotizing enterocolitis (NEC), and yet the contribution of antioxidant response (ARE) gene polymorphisms to NEC risk remains unknown. Premature infants recruited in a multicenter study were genotyped for 6 ARE variants. Among 637 infants, 52 had NEC, and 22 developed surgical NEC. Gestational age <28 weeks (P < 0.02) and African American race (P = 0.03) were associated with NEC. The NFE2L2 (rs6721961), SOD2 (rs4880), GSTP1 (rs1695), NQO1 (rs1800566), GCLC (rs17883901), and HMOX1 (rs2071747) variants were not associated with medical or surgical NEC. This study does not support a role for common deleterious ARE variants in NEC.

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Year:  2016        PMID： 26426434      PMCID： PMC5055643          DOI： 10.1097/MPG.0000000000000988

Source DB:  PubMed          Journal:  J Pediatr Gastroenterol Nutr        ISSN： 0277-2116            Impact factor:   2.839


  30 in total

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3.  SIGIRR genetic variants in premature infants with necrotizing enterocolitis.

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Review 4.  New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond.

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5.  May oxidative stress biomarkers in cord blood predict the occurrence of necrotizing enterocolitis in preterm infants?

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Review 10.  The role of oxidative stress on necrotizing enterocolitis in very low birth weight infants.

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