| Literature DB >> 26426420 |
Chun Xu1, Meihua Yu1, Owen Noonan1, Jun Zhang1, Hao Song1, Hongwei Zhang1, Chang Lei1, Yuting Niu1, Xiaodan Huang1, Yannan Yang1, Chengzhong Yu1.
Abstract
A new type of monodispersed mesoporous silica nanoparticles with a core-cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm(3) g(-1). MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights.Entities:
Keywords: large pores; mesoporous silica; nanoparticles; protein delivery
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Year: 2015 PMID： 26426420 DOI： 10.1002/smll.201501449
Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281