Literature DB >> 26426251

Cancer-Cell-Specific Nuclear-Targeted Drug Delivery by Dual-Ligand-Modified Mesoporous Silica Nanoparticles.

Lin Xiong1, Xin Du1, Freddy Kleitz2, Shi Zhang Qiao1.   

Abstract

Mesoporous silica nanoparticles are modified with dual targeting ligands, i.e., folic acid and dexamethasone, to construct a cancer-cell-specific nuclear-targeted delivery system. The resulting nanocarriers can not only enhance the inhibition efficacy of doxorubicin on Hela cells through active nucleus accumulation but also reduce toxic side effects on noncancer cells though receptor-mediated selective cellular uptake.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  cancer therapy; dexamethasone; doxorubicin; drug delivery; mesoporous silica

Mesh：

Substances：

Year:  2015        PMID： 26426251     DOI： 10.1002/smll.201501056

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  10 in total

1.  Targeted delivery of in situ PCR-amplified Sleeping Beauty transposon genes to cancer cells with lipid-based nanoparticle-like protocells.

Authors:  Kun Ma; Duo Fu; Dongli Yu; Changhao Cui; Li Wang; Zhaoming Guo; Chuanbin Mao
Journal:  Biomaterials       Date:  2017-01-02       Impact factor: 12.479

2.  A Facile Approach to Upconversion Crystalline CaF2:Yb3+,Tm3+@mSiO2 Nanospheres for Tumor Therapy.

Authors:  Yangyang Li; Yurong Zhou; Xiang Li; Jihong Sun; Zhaohui Ren; Wengjian Wen; Xiaoming Yang; Gaorong Han
Journal:  RSC Adv       Date:  2016-04-13       Impact factor: 3.361

Review 3.  Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

Authors:  María Vallet-Regí; Ferdi Schüth; Daniel Lozano; Montserrat Colilla; Miguel Manzano
Journal:  Chem Soc Rev       Date:  2022-07-04       Impact factor: 60.615

Review 4.  Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update.

Authors:  Rafael R Castillo; Daniel Lozano; Blanca González; Miguel Manzano; Isabel Izquierdo-Barba; María Vallet-Regí
Journal:  Expert Opin Drug Deliv       Date:  2019-04-22       Impact factor: 6.648

5.  In vitro evaluation of folic acid-conjugated redox-responsive mesoporous silica nanoparticles for the delivery of cisplatin.

Authors:  Merlis P Alvarez-Berríos; Juan L Vivero-Escoto
Journal:  Int J Nanomedicine       Date:  2016-11-23

Review 6.  Active Cellular and Subcellular Targeting of Nanoparticles for Drug Delivery.

Authors:  Okhil K Nag; James B Delehanty
Journal:  Pharmaceutics       Date:  2019-10-18       Impact factor: 6.321

Review 7.  Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy.

Authors:  Thashini Moodley; Moganavelli Singh
Journal:  Pharmaceutics       Date:  2021-01-07       Impact factor: 6.321

8.  Exploitation of High Tumour GSH Levels for Targeted siRNA Delivery in Rhabdomyosarcoma Cells.

Authors:  Chengchen Duan; Helen Townley
Journal:  Biomolecules       Date:  2022-08-17

Review 9.  Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles.

Authors:  Miguel Gisbert-Garzarán; María Vallet-Regí
Journal:  Nanomaterials (Basel)       Date:  2020-05-09       Impact factor: 5.076

Review 10.  Sequential Drug Delivery in Targeted Cancer Therapy.

Authors:  Han Yu; Na Ning; Xi Meng; Chuda Chittasupho; Lingling Jiang; Yunqi Zhao
Journal:  Pharmaceutics       Date:  2022-03-05       Impact factor: 6.321
  10 in total

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