Literature DB >> 26425906

A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and Medical Countermeasure Development.

Claire L Carter1, Jace W Jones, Kory Barrow, Kaitlyn Kieta, Cheryl Taylor-Howell, Sean Kearney, Cassandra P Smith, Allison Gibbs, Ann M Farese, Thomas J MacVittie, Maureen A Kane.   

Abstract

Radiation-induced lung injury is highly complex and characterized by multiple pathologies, which occur over time and sporadically throughout the lung. This complexity makes biomarker investigations and medical countermeasure screenings challenging. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has the ability to resolve differences spatially in molecular profiles within the lung following radiation exposure and can aid in biomarker identification and pharmaceutical efficacy investigations. MALDI-MSI was applied to the investigation of a whole-thorax lung irradiation model in non-human primates (NHP) for lipidomic analysis and medical countermeasure distribution.

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Year:  2015        PMID： 26425906      PMCID： PMC4745118          DOI： 10.1097/HP.0000000000000353

Source DB:  PubMed          Journal:  Health Phys        ISSN： 0017-9078            Impact factor:   1.316


  72 in total

1.  Sucrose cryo-protection facilitates imaging of whole eye sections by MALDI mass spectrometry.

Authors:  Andrew D Palmer; Rian Griffiths; Iain Styles; Ela Claridge; Antonio Calcagni; Josephine Bunch
Journal:  J Mass Spectrom       Date:  2012-02       Impact factor: 1.982

Review 2.  On the future of mass-spectrometry-based lipidomics.

Authors:  Ursula Loizides-Mangold
Journal:  FEBS J       Date:  2013-03-13       Impact factor: 5.542

3.  Pegfilgrastim administered in an abbreviated schedule, significantly improved neutrophil recovery after high-dose radiation-induced myelosuppression in rhesus macaques.

Authors:  A M Farese; M V Cohen; R B Stead; W Jackson; T J Macvittie
Journal:  Radiat Res       Date:  2012-09-19       Impact factor: 2.841

Review 4.  Idiopathic pulmonary fibrosis.

Authors:  Talmadge E King; Annie Pardo; Moisés Selman
Journal:  Lancet       Date:  2011-06-28       Impact factor: 79.321

5.  Acute gastrointestinal syndrome in high-dose irradiated mice.

Authors:  Catherine Booth; Gregory Tudor; Julie Tudor; Barry P Katz; Thomas J MacVittie
Journal:  Health Phys       Date:  2012-10       Impact factor: 1.316

6.  Evidence of delayed gastrointestinal syndrome in high-dose irradiated mice.

Authors:  Catherine Booth; Gregory Tudor; Nicola Tonge; Terez Shea-Donohue; Thomas J MacVittie
Journal:  Health Phys       Date:  2012-10       Impact factor: 1.316

7.  Cholesterol sulfate induces expression of the skin barrier protein filaggrin in normal human epidermal keratinocytes through induction of RORα.

Authors:  Osamu Hanyu; Hanako Nakae; Takashi Miida; Yuko Higashi; Hirotoshi Fuda; Motohiro Endo; Atsushi Kohjitani; Hirohito Sone; Charles A Strott
Journal:  Biochem Biophys Res Commun       Date:  2012-10-12       Impact factor: 3.575

8.  Filgrastim improves survival in lethally irradiated nonhuman primates.

Authors:  Ann M Farese; Melanie V Cohen; Barry P Katz; Cassandra P Smith; Allison Gibbs; Daniel M Cohen; Thomas J MacVittie
Journal:  Radiat Res       Date:  2012-12-04       Impact factor: 2.841

9.  Repeat MALDI MS imaging of a single tissue section using multiple matrices and tissue washes.

Authors:  Rory T Steven; Josephine Bunch
Journal:  Anal Bioanal Chem       Date:  2013-03-21       Impact factor: 4.142

10.  Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors.

Authors:  Hui Lin Chua; P Artur Plett; Carol H Sampson; Barry P Katz; Gilbert W Carnathan; Thomas J MacVittie; Keith Lenden; Christie M Orschell
Journal:  Health Phys       Date:  2014-01       Impact factor: 1.316
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  10 in total

Review 1.  Nonhuman primates as models for the discovery and development of radiation countermeasures.

Authors:  Vijay K Singh; Ayodele O Olabisi
Journal:  Expert Opin Drug Discov       Date:  2017-05-05       Impact factor: 6.098

2.  Acute Proteomic Changes in the Lung After WTLI in a Mouse Model: Identification of Potential Initiating Events for Delayed Effects of Acute Radiation Exposure.

Authors:  Weiliang Huang; Jianshi Yu; Jace W Jones; Claire L Carter; I Lauren Jackson; Zeljko Vujaskovic; Thomas J MacVittie; Maureen A Kane
Journal:  Health Phys       Date:  2019-04       Impact factor: 1.316

3.  An optimized method for the detection and spatial distribution of aminoglycoside and vancomycin antibiotics in tissue sections by mass spectrometry imaging.

Authors:  Ning Wang; Véronique Dartois; Claire L Carter
Journal:  J Mass Spectrom       Date:  2021-03       Impact factor: 1.982

Review 4.  Radiation-Induced Lung Injury: Assessment and Management.

Authors:  Alexander N Hanania; Walker Mainwaring; Yohannes T Ghebre; Nicola A Hanania; Michelle Ludwig
Journal:  Chest       Date:  2019-04-15       Impact factor: 9.410

5.  Animal Models: A Non-human Primate and Rodent Animal Model Research Platform, Natural History, and Biomarkers to Predict Clinical Outcome.

Authors:  Thomas J MacVittie; Ann M Farese; Maureen A Kane
Journal:  Health Phys       Date:  2021-10-01       Impact factor: 2.922

6.  Characterizing the Natural History of Acute Radiation Syndrome of the Gastrointestinal Tract: Combining High Mass and Spatial Resolution Using MALDI-FTICR-MSI.

Authors:  Claire L Carter; Kim G Hankey; Catherine Booth; Gregory L Tudor; George A Parker; Jace W Jones; Ann M Farese; Thomas J MacVittie; Maureen A Kane
Journal:  Health Phys       Date:  2019-04       Impact factor: 1.316

7.  Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 Mitigation of Radiation-Induced Lung Injury.

Authors:  Jace W Jones; Isabel L Jackson; Zeljko Vujaskovic; Michael D Kaytor; Maureen A Kane
Journal:  Pharm Res       Date:  2017-10-02       Impact factor: 4.200

8.  Proteomics of Non-human Primate Plasma after Partial-body Radiation with Minimal Bone Marrow Sparing.

Authors:  Weiliang Huang; Jianshi Yu; Tian Liu; Amy E Defnet; Stephanie Zalesak; Ann M Farese; Thomas J MacVittie; Maureen A Kane
Journal:  Health Phys       Date:  2020-11       Impact factor: 2.922

9.  Lipidomic dysregulation within the lung parenchyma following whole-thorax lung irradiation: Markers of injury, inflammation and fibrosis detected by MALDI-MSI.

Authors:  Claire L Carter; Jace W Jones; Ann M Farese; Thomas J MacVittie; Maureen A Kane
Journal:  Sci Rep       Date:  2017-09-04       Impact factor: 4.379

10.  MALDI-MSI spatially maps N-glycan alterations to histologically distinct pulmonary pathologies following irradiation.

Authors:  Claire L Carter; George A Parker; Kim G Hankey; Ann M Farese; Thomas J MacVittie; Maureen A Kane
Journal:  Sci Rep       Date:  2020-07-14       Impact factor: 4.379
  10 in total

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