| Literature DB >> 26424644 |
Abstract
EBV latent infection is characterized by a highly restricted pattern of viral gene expression. EBV can establish latent infections in multiple different tissue types with remarkable variation and plasticity in viral transcription and replication. During latency, the viral genome persists as a multi-copy episome, a non-integrated-closed circular DNA with nucleosome structure similar to cellular chromosomes. Chromatin assembly and histone modifications contribute to the regulation of viral gene expression, DNA replication, and episome persistence during latency. This review focuses on how EBV latency is regulated by chromatin and its associated processes.Entities:
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Year: 2015 PMID： 26424644 DOI： 10.1007/978-3-319-22822-8_5
Source DB: PubMed Journal: Curr Top Microbiol Immunol ISSN： 0070-217X Impact factor: 4.291