OBJECTIVE: The aim of the study was to investigate the relation between health-related quality of life (HRQoL) and left ventricular systolic and diastolic function parameters in stable coronary artery disease (CAD) patients with mild and moderate heart failure. MATERIALS AND METHODS: This study included 758 CAD patients. Left ventricular ejection fraction (LVEF) and ratio of peak velocities of early (E) and late (A) diastolic mitral inflow, ratio E/A, deceleration time, isovolumic relaxation time were assessed. Patients completed the SF-36 questionnaire. RESULTS: There were no strong and significant associations between echocardiographic measures and HRQoL in NYHA I-II class patients. In NYHA III class in univariate linear regression analyses significant associations were found between LVEF and physical functioning (β=0.230, P=0.009) and role limitations due to physical problems (β=0.230, P=0.009) and these associations remain significant after adjustment for age, gender, hypertension, angina pectoris class, nitrate, ACE inhibitors and diuretics use. E/A ratio was significantly associated only with mental health domain (β=0.188, P=0.048), and this association remains significant after all adjustments. CONCLUSIONS: In stable CAD patients with NYHA I-II functional class HRQoL was not strongly associated with left ventricular function; in NYHA III functional class patients' greater systolic function mainly was associated with better physical health and better diastolic function, with better mental health.
OBJECTIVE: The aim of the study was to investigate the relation between health-related quality of life (HRQoL) and left ventricular systolic and diastolic function parameters in stable coronary artery disease (CAD) patients with mild and moderate heart failure. MATERIALS AND METHODS: This study included 758 CAD patients. Left ventricular ejection fraction (LVEF) and ratio of peak velocities of early (E) and late (A) diastolic mitral inflow, ratio E/A, deceleration time, isovolumic relaxation time were assessed. Patients completed the SF-36 questionnaire. RESULTS: There were no strong and significant associations between echocardiographic measures and HRQoL in NYHA I-II class patients. In NYHA III class in univariate linear regression analyses significant associations were found between LVEF and physical functioning (β=0.230, P=0.009) and role limitations due to physical problems (β=0.230, P=0.009) and these associations remain significant after adjustment for age, gender, hypertension, angina pectoris class, nitrate, ACE inhibitors and diuretics use. E/A ratio was significantly associated only with mental health domain (β=0.188, P=0.048), and this association remains significant after all adjustments. CONCLUSIONS: In stable CAD patients with NYHA I-II functional class HRQoL was not strongly associated with left ventricular function; in NYHA III functional class patients' greater systolic function mainly was associated with better physical health and better diastolic function, with better mental health.
Authors: Yevgeniy Khariton; Sophia Airhart; Adam C Salisbury; John A Spertus; Kensey L Gosch; J Aaron Grantham; Dimitrios Karmpaliotis; Jeffrey W Moses; William J Nicholson; David J Cohen; William Lombardi; James Sapontis; James M McCabe Journal: JACC Cardiovasc Interv Date: 2018-11-26 Impact factor: 11.195
Authors: Marta Kałużna-Oleksy; Filip Sawczak; Agata Kukfisz; Helena Krysztofiak; Magdalena Szczechla; Marta Wleklik; Katarzyna Przytarska; Magdalena Dudek; Alicja Nowak; Ewa Straburzyńska-Migaj; Bartosz Uchmanowicz Journal: Int J Environ Res Public Health Date: 2021-11-26 Impact factor: 3.390