Edita Jankauskienė1, Paulius Orda2, Eglė Rumbinaitė3, Diana Žaliaduonytė-Pekšienė4, Rasa Steponavičiutė5, Aurelija Krasauskienė6, Jolanta Justina Vaškelytė7, Robertas Bunevičius8. 1. Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: editajank1@gmail.com. 2. Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: pauliusorda@gmail.com. 3. Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: egle.rumbinaite@gmail.com. 4. Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: Diana.Peksiene@lsmuni.lt. 5. Department of Laboratory Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: rasastepkons@gmail.com. 6. Department of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: aurelija.krasauskiene@gmail.com. 7. Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: jvaskelyte@gmail.com. 8. Behavioral Medicine Institute, Medical Academy, Lithuanian University of Health Sciences, Palanga, Lithuania.
Abstract
BACKGROUND AND OBJECTIVE: Low-T3 syndrome is common in patients with acute myocardial infarction (AMI). Recent experimental and clinical data have suggested a potential negative impact of low-T3 syndrome on myocardial function in patients with AMI. The aim of this study was to assess left ventricular (LV) myocardial function in patients with low-T3 syndrome and to investigate the association between hormonal profile and the severity of LV dysfunction using speckle-tracking echocardiography (STE). MATERIALS AND METHODS: In 130 patients with first-onset ST-segment elevation acute myocardial infarction (STEMI), conventional 2D and speckle-tracking echocardiography within 48-72h after the hospitalization was performed, and blood samples for TSH, fT4, fT3, and anti-TPO levels were obtained to investigate thyroid hormone production within 24h and on the fourth day after the onset of STEMI symptoms. RESULTS: The patients were divided into two groups according to their serum level of fT3: group 1 with fT3 concentration below 3.2pmol/L (n=34) and group 2 with normal fT3 (>3.2pmol/L) level (n=96). LV ejection fraction (EF) tended to be lower in the low fT3 group. The systolic longitudinal strain did not differ between the groups, but the late diastolic longitudinal strain rate was lower in group 1 (P=0.011). The systolic basal LV rotation positively correlated with the level of fT3 (r=0.4; P<0.001), while a negative correlation was detected between myocardial rotational parameters - systolic apical rotation (r=-0.2; P<0.05), torsion (r=-0.3; P<0.001), and diastolic apical rotation rate (r=-0.3; P<0.01) - and fT3 levels. CONCLUSIONS: The late diastolic longitudinal LV strain rate and LV rotation evaluated by speckle-tracking echocardiography were impaired in patients with low-T3 syndrome after AMI.
BACKGROUND AND OBJECTIVE:Low-T3 syndrome is common in patients with acute myocardial infarction (AMI). Recent experimental and clinical data have suggested a potential negative impact of low-T3 syndrome on myocardial function in patients with AMI. The aim of this study was to assess left ventricular (LV) myocardial function in patients with low-T3 syndrome and to investigate the association between hormonal profile and the severity of LV dysfunction using speckle-tracking echocardiography (STE). MATERIALS AND METHODS: In 130 patients with first-onset ST-segment elevation acute myocardial infarction (STEMI), conventional 2D and speckle-tracking echocardiography within 48-72h after the hospitalization was performed, and blood samples for TSH, fT4, fT3, and anti-TPO levels were obtained to investigate thyroid hormone production within 24h and on the fourth day after the onset of STEMI symptoms. RESULTS: The patients were divided into two groups according to their serum level of fT3: group 1 with fT3 concentration below 3.2pmol/L (n=34) and group 2 with normal fT3 (>3.2pmol/L) level (n=96). LV ejection fraction (EF) tended to be lower in the low fT3 group. The systolic longitudinal strain did not differ between the groups, but the late diastolic longitudinal strain rate was lower in group 1 (P=0.011). The systolic basal LV rotation positively correlated with the level of fT3 (r=0.4; P<0.001), while a negative correlation was detected between myocardial rotational parameters - systolic apical rotation (r=-0.2; P<0.05), torsion (r=-0.3; P<0.001), and diastolic apical rotation rate (r=-0.3; P<0.01) - and fT3 levels. CONCLUSIONS: The late diastolic longitudinal LV strain rate and LV rotation evaluated by speckle-tracking echocardiography were impaired in patients with low-T3 syndrome after AMI.
Authors: Edita Jankauskienė; Paulius Orda; Greta Barauskienė; Narseta Mickuvienė; Julija Brožaitienė; Jolanta Justina Vaškelytė; Robertas Bunevičius Journal: Intern Emerg Med Date: 2015-12-21 Impact factor: 3.397