Daniela Moré Gorzilio1, Elisa Garrido2, Cláudia Maria Gaspardo2, Francisco Eulogio Martinez2, Maria Beatriz Martins Linhares3. 1. Faculty of Philosophy, Sciences and Letters, University of São Paulo, Avenida Bandeirantes, 3900, Ribeirão Preto, SP CEP: 14040-901, Brazil; Hospital of Clinics, Ribeirão Preto Medical School, University of São Paulo, Campus Universitário s/n, Ribeirão Preto, SP CEP: 14048-900, Brazil. 2. Ribeirão Preto Medical School, University of São Paulo, Avenida Tenente Catão Roxo, 2260, Ribeirão Preto, SP CEP: 14051-140, Brazil. 3. Ribeirão Preto Medical School, University of São Paulo, Avenida Tenente Catão Roxo, 2260, Ribeirão Preto, SP CEP: 14051-140, Brazil. Electronic address: linhares@fmrp.usp.br.
Abstract
BACKGROUND: Neonatal Intensive Care Units (NICUs) protect preterm infants; otherwise, this is a stressful environment including painful stimuli. AIMS: To compare early neurobehavioral development prior to term-age in preterm infants at 34-36weeks of post-conceptional age in different gestational ages, and to examine the effects of prematurity level and acute stressful events during NICU hospitalization on neurobehavioral development. STUDY DESIGN: Cross-sectional design. SUBJECTS: Forth-five preterm infants, 34-36weeks of post-conceptional age, were distributed into groups: extreme preterm (EPT; 23-28weeks of gestational age; n=10), moderate preterm (MPT; 29-32weeks of gestational age; n=10), late preterm (LPT; 34-36weeks of gestational age; n=25). OUTCOME MEASURES: All of the neonates were evaluated using the Neurobehavioral Assessment of Preterm Infant (NAPI) prior to 37weeks of post-conceptional age. The Neonatal Infant Stressor Scale (NISS) was applied for EPT and MPT infants during NICU hospitalization, and medical charts were analyzed. RESULTS: The EPT group experienced significantly more acute stressful events during NICU hospitalization than the MPT group. The MPT group had lower scores in motor development and vigor than the EPT and LPT group, and they exhibited poorer quality crying than the LPT group. Motor development and vigor and alertness and orientation in preterm infants were predicted by prematurity level and acute stressful events. CONCLUSION: The extreme preterm was exposed to higher stressful experiences than moderate and late preterm infants. However, the moderate preterm infants presented more vulnerable than the other counterparts in motor and vigor outcomes.
BACKGROUND: Neonatal Intensive Care Units (NICUs) protect preterm infants; otherwise, this is a stressful environment including painful stimuli. AIMS: To compare early neurobehavioral development prior to term-age in preterm infants at 34-36weeks of post-conceptional age in different gestational ages, and to examine the effects of prematurity level and acute stressful events during NICU hospitalization on neurobehavioral development. STUDY DESIGN: Cross-sectional design. SUBJECTS: Forth-five preterm infants, 34-36weeks of post-conceptional age, were distributed into groups: extreme preterm (EPT; 23-28weeks of gestational age; n=10), moderate preterm (MPT; 29-32weeks of gestational age; n=10), late preterm (LPT; 34-36weeks of gestational age; n=25). OUTCOME MEASURES: All of the neonates were evaluated using the Neurobehavioral Assessment of Preterm Infant (NAPI) prior to 37weeks of post-conceptional age. The Neonatal Infant Stressor Scale (NISS) was applied for EPT and MPTinfants during NICU hospitalization, and medical charts were analyzed. RESULTS: The EPT group experienced significantly more acute stressful events during NICU hospitalization than the MPT group. The MPT group had lower scores in motor development and vigor than the EPT and LPT group, and they exhibited poorer quality crying than the LPT group. Motor development and vigor and alertness and orientation in preterm infants were predicted by prematurity level and acute stressful events. CONCLUSION: The extreme preterm was exposed to higher stressful experiences than moderate and late preterm infants. However, the moderate preterm infants presented more vulnerable than the other counterparts in motor and vigor outcomes.
Authors: Abbey L Eeles; Jennifer M Walsh; Joy E Olsen; Rocco Cuzzilla; Deanne K Thompson; Peter J Anderson; Lex W Doyle; Jeanie L Y Cheong; Alicia J Spittle Journal: BMJ Paediatr Open Date: 2017-10-05
Authors: Inalu Barbosa da Silva; Paola Andrade Gomes da Cunha; Maria Beatriz Martins Linhares; Francisco Eulógio Martinez; José Simon Camelo Júnior Journal: Rev Paul Pediatr Date: 2018-10-29