| Literature DB >> 26422788 |
Carlotta Pontremoli1, Nadia Barbero2, Guido Viscardi2, Sonja Visentin3.
Abstract
The binding of mucin with three commercially available drugs (theophylline, cephalexin and prednisolone) belonging to different pharmaceutical classes was investigated. The studied drugs are normally used to treat the symptomatology of cystic fibrosis. The interaction between drugs and mucin has been investigated using fluorescence and UV-Vis absorption spectroscopy; quenching mechanism, binding constants, binding sites, thermodynamic parameters and binding distance of the interaction were obtained.Entities:
Keywords: Drugs; FRET; Interaction; Mucin; UV–Vis and fluorescence spectroscopy
Mesh：
Substances：
Year: 2015 PMID： 26422788 DOI： 10.1016/j.bmc.2015.09.021
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641