Gian Marco Rosa1, Simone Ferrero1, Victor W Nitti2, Adrian Wagg3, Tahir Saleem4, Christopher R Chapple5. 1. IRCCS AOU San Martino - University of Genoa, Genoa, Italy. 2. Department of Urology, NYU Langone Medical Center, New York, NY, USA. 3. Division of Geriatric Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. 4. Astellas Pharma Europe Ltd, Chertsey, Surrey, UK. 5. Department of Urology, Royal Hallamshire Hospital, Sheffield, UK. Electronic address: c.r.chapple@shef.ac.uk.
Abstract
CONTEXT: Mirabegron, the first β3-adrenoceptor agonist in clinical practice, is approved for treatment of overactive bladder (OAB) syndrome symptoms. Because β3-adrenoceptors are expressed in cardiovascular (CV) tissues, there are concerns that OAB treatment with β3-adrenoceptor agonists may affect the heart and vasculature. OBJECTIVE: To provide a summary of CV effects of β3-adrenoceptor agonists in clinical studies. EVIDENCE ACQUISITION: A systematic literature search from inception until November 2014 was performed on studies in PubMed and Medline. EVIDENCE SYNTHESIS: Twenty papers, published between 1994 and 2014, were identified: mirabegron (16), solabegron (2), AK-677 (1), and BRL35135 (1). More detailed CV data from mirabegron studies were available in online regulatory documents filed with the US Food and Drug Administration and the UK National Institute for Health and Care Excellence. CONCLUSIONS: The CV safety of mirabegron appears to be acceptable at therapeutic doses and comparable with that of antimuscarinic agents, currently first-line therapy for OAB. PATIENT SUMMARY: In this review we looked at the cardiovascular (CV) effects of β3-adrenoceptor agonists used for the treatment of overactive bladder (OAB). The CV safety of mirabegron (the only clinically approved β3-adrenoceptor agonist) appears to be acceptable at therapeutic doses and comparable with that of antimuscarinic agents, the current first-line therapy for OAB.
CONTEXT: Mirabegron, the first β3-adrenoceptor agonist in clinical practice, is approved for treatment of overactive bladder (OAB) syndrome symptoms. Because β3-adrenoceptors are expressed in cardiovascular (CV) tissues, there are concerns that OAB treatment with β3-adrenoceptor agonists may affect the heart and vasculature. OBJECTIVE: To provide a summary of CV effects of β3-adrenoceptor agonists in clinical studies. EVIDENCE ACQUISITION: A systematic literature search from inception until November 2014 was performed on studies in PubMed and Medline. EVIDENCE SYNTHESIS: Twenty papers, published between 1994 and 2014, were identified: mirabegron (16), solabegron (2), AK-677 (1), and BRL35135 (1). More detailed CV data from mirabegron studies were available in online regulatory documents filed with the US Food and Drug Administration and the UK National Institute for Health and Care Excellence. CONCLUSIONS: The CV safety of mirabegron appears to be acceptable at therapeutic doses and comparable with that of antimuscarinic agents, currently first-line therapy for OAB. PATIENT SUMMARY: In this review we looked at the cardiovascular (CV) effects of β3-adrenoceptor agonists used for the treatment of overactive bladder (OAB). The CV safety of mirabegron (the only clinically approved β3-adrenoceptor agonist) appears to be acceptable at therapeutic doses and comparable with that of antimuscarinic agents, the current first-line therapy for OAB.
Authors: Andrea Tubaro; José E Batista; Victor W Nitti; Sender Herschorn; Christopher R Chapple; Mary Beth Blauwet; Emad Siddiqui; Moses Huang; Matthias Oelke Journal: Ther Adv Urol Date: 2017-05-10
Authors: Kristen J Bubb; Dhanya Ravindran; Siân P Cartland; Meghan Finemore; Zoe E Clayton; Michael Tsang; Owen Tang; Mary M Kavurma; Sanjay Patel; Gemma A Figtree Journal: Front Pharmacol Date: 2021-04-22 Impact factor: 5.810