Literature DB >> 26422623

Epigenetic control of podocyte differentiation: a new target of the renin-angiotensin system in kidney disease.

Denis Feliers1.   

Abstract

Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.

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Year:  2015        PMID： 26422623     DOI： 10.1038/ki.2015.224

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  9 in total

Review 1.  Antiproteinuric effect of RAS blockade: new mechanisms.

Authors:  Markus Lassila; Mark E Cooper; Karin Jandeleit-Dahm
Journal:  Curr Hypertens Rep       Date:  2004-10       Impact factor: 5.369

2.  Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-κB and silenced by DNA methylation.

Authors:  Mervi Ristola; Satu Arpiainen; Moin A Saleem; Harry Holthöfer; Sanna Lehtonen
Journal:  Nephrol Dial Transplant       Date:  2011-10-06       Impact factor: 5.992

3.  Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria.

Authors:  Kaori Hayashi; Hiroyuki Sasamura; Mari Nakamura; Yusuke Sakamaki; Tatsuhiko Azegami; Hideyo Oguchi; Hirobumi Tokuyama; Shu Wakino; Koichi Hayashi; Hiroshi Itoh
Journal:  Kidney Int       Date:  2015-06-24       Impact factor: 10.612

4.  KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria.

Authors:  Kaori Hayashi; Hiroyuki Sasamura; Mari Nakamura; Tatsuhiko Azegami; Hideyo Oguchi; Yusuke Sakamaki; Hiroshi Itoh
Journal:  J Clin Invest       Date:  2014-05-08       Impact factor: 14.808

5.  UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9.

Authors:  Xiaoli Liu; Qinqin Gao; Pishun Li; Qian Zhao; Jiqin Zhang; Jiwen Li; Haruhiko Koseki; Jiemin Wong
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

6.  Glomerular mRNA expression of prothrombotic and antithrombotic factors in renal transplants with thrombotic microangiopathy.

Authors:  Putri Andina Agustian; Clemens Luitpold Bockmeyer; Friedrich Modde; Juliane Wittig; Falko Markus Heinemann; Stephanie Brundiers; Maximilian Ernst Dämmrich; Anke Schwarz; Ingvild Birschmann; Barbara Suwelack; Peter Thomas Jindra; Thurid Ahlenstiel; Jeremias Wohlschläger; Udo Vester; Tina Ganzenmüller; Eva Zilian; Thorsten Feldkamp; Tilmann Spieker; Stephan Immenschuh; Hans Heinrich Kreipe; Verena Bröcker; Jan Ulrich Becker
Journal:  Transplantation       Date:  2013-05-27       Impact factor: 4.939

7.  MG98, a second-generation DNMT1 inhibitor, in the treatment of advanced renal cell carcinoma.

Authors:  Robert J Amato; Joe Stephenson; Sebastien Hotte; John Nemunaitis; Karl Bélanger; Gregory Reid; Robert E Martell
Journal:  Cancer Invest       Date:  2012-06       Impact factor: 2.176

8.  Epigenetic repression of Krüppel-like factor 4 through Dnmt1 contributes to EMT in renal fibrosis.

Authors:  Xiangcheng Xiao; Wenbin Tang; Qiongjing Yuan; Ling Peng; Pingping Yu
Journal:  Int J Mol Med       Date:  2015-04-20       Impact factor: 4.101

Review 9.  Review series: The cell biology of renal filtration.

Authors:  Rizaldy P Scott; Susan E Quaggin
Journal:  J Cell Biol       Date:  2015-04-27       Impact factor: 10.539
  9 in total
  4 in total

1.  A KDM6A-KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction.

Authors:  Chun-Liang Lin; Yung-Chien Hsu; Yu-Ting Huang; Ya-Hsueh Shih; Ching-Jen Wang; Wen-Chih Chiang; Pey-Jium Chang
Journal:  EMBO Mol Med       Date:  2019-05       Impact factor: 12.137

2.  ROS/RNS Balancing, Aerobic Fermentation Regulation and Cell Cycle Control - a Complex Early Trait ('CoV-MAC-TED') for Combating SARS-CoV-2-Induced Cell Reprogramming.

Authors:  José Hélio Costa; Gunasekaran Mohanapriya; Revuru Bharadwaj; Carlos Noceda; Karine Leitão Lima Thiers; Shahid Aziz; Shivani Srivastava; Manuela Oliveira; Kapuganti Jagadis Gupta; Aprajita Kumari; Debabrata Sircar; Sarma Rajeev Kumar; Arvind Achra; Ramalingam Sathishkumar; Alok Adholeya; Birgit Arnholdt-Schmitt
Journal:  Front Immunol       Date:  2021-07-07       Impact factor: 7.561

3.  Early type 1 diabetes aggravates renal ischemia/reperfusion-induced acute kidney injury.

Authors:  Mariana Charleaux de Ponte; Vanessa Gerolde Cardoso; Guilherme Lopes Gonçalves; Juliana Martins Costa-Pessoa; Maria Oliveira-Souza
Journal:  Sci Rep       Date:  2021-09-24       Impact factor: 4.379

4.  hsa-miR-199b-3p Prevents the Epithelial-Mesenchymal Transition and Dysfunction of the Renal Tubule by Regulating E-cadherin through Targeting KDM6A in Diabetic Nephropathy.

Authors:  Shoujun Bai; Xiaoyan Xiong; Bo Tang; Tingting Ji; Xiaoying Li; Xiaolei Qu; Weiliang Li
Journal:  Oxid Med Cell Longev       Date:  2021-06-27       Impact factor: 6.543
  4 in total

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