Literature DB >> 26420800

Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry.

Osnat Rosen1, Liron Feldberg2, Sigalit Gura2, Tal Brosh-Nissimov3, Alex Guri4, Oren Zimhony4, Eli Shapiro5, Adi Beth-Din6, Dana Stein6, Eyal Ozeri1, Ada Barnea1, Amram Turgeman1, Alon Ben David1, Arieh Schwartz1, Eytan Elhanany6, Eran Diamant1, Shmuel Yitzhaki7, Ran Zichel1.   

Abstract

Botulinum toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conventional tests provided negative results. Antitoxin was administered, resulting in patient improvement. Implementing this highly sensitive and rapid assay will improve preparedness for foodborne botulism and deliberate exposure.
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Endopep-MS; botulism; diagnosis

Mesh:

Substances:

Year:  2015        PMID: 26420800     DOI: 10.1093/cid/civ861

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN: 1058-4838            Impact factor:   9.079


  4 in total

1.  Development of an Innovative in Vitro Potency Assay for Anti-Botulinum Antitoxins.

Authors:  Osnat Rosen; Eyal Ozeri; Ada Barnea; Alon Ben David; Ran Zichel
Journal:  Toxins (Basel)       Date:  2016-09-24       Impact factor: 4.546

Review 2.  Toxins as biological weapons for terror-characteristics, challenges and medical countermeasures: a mini-review.

Authors:  Tamar Berger; Arik Eisenkraft; Erez Bar-Haim; Michael Kassirer; Adi Avniel Aran; Itay Fogel
Journal:  Disaster Mil Med       Date:  2016-04-29

Review 3.  Proteomic Methods of Detection and Quantification of Protein Toxins.

Authors:  Miloslava Duracova; Jana Klimentova; Alena Fucikova; Jiri Dresler
Journal:  Toxins (Basel)       Date:  2018-02-28       Impact factor: 4.546

4.  Development of a multiplex Endopep-MS assay for simultaneous detection of botulinum toxins A, B and E.

Authors:  Osnat Rosen; Liron Feldberg; Tamar Shamai Yamin; Eyal Dor; Ada Barnea; Avi Weissberg; Ran Zichel
Journal:  Sci Rep       Date:  2017-11-01       Impact factor: 4.379

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.