Literature DB >> 26418302

Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.

Sijumon Kunjachan1, Alexandre Detappe1,2, Rajiv Kumar1,3, Thomas Ireland4, Lisa Cameron5, Douglas E Biancur1, Vincent Motto-Ros2, Lucie Sancey2, Srinivas Sridhar1,3, G Mike Makrigiorgos1, Ross I Berbeco1.   

Abstract

More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.

Entities:  

Keywords:  Gold nanoparticles; endothelial radiation damage; image-guided radiation therapy; tumor vascular disruption

Mesh：

Substances：

Year:  2015        PMID： 26418302      PMCID： PMC5507193          DOI： 10.1021/acs.nanolett.5b03073

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  57 in total

1.  Localized dose enhancement to tumor blood vessel endothelial cells via megavoltage X-rays and targeted gold nanoparticles: new potential for external beam radiotherapy.

Authors:  Ross I Berbeco; Wilfred Ngwa; G Mike Makrigiorgos
Journal:  Int J Radiat Oncol Biol Phys       Date:  2010-12-14       Impact factor: 7.038

2.  Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.

Authors:  B Devika Chithrani; Arezou A Ghazani; Warren C W Chan
Journal:  Nano Lett       Date:  2006-04       Impact factor: 11.189

3.  Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy.

Authors:  Xiao-Dong Zhang; Di Wu; Xiu Shen; Jie Chen; Yuan-Ming Sun; Pei-Xun Liu; Xing-Jie Liang
Journal:  Biomaterials       Date:  2012-06-07       Impact factor: 12.479

4.  Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization.

Authors:  Jay F Dorsey; Lova Sun; Daniel Y Joh; Alon Witztum; Gary D Kao; Michelle Alonso-Basanta; Stephen Avery; Stephen M Hahn; Ajlan Al Zaki; Andrew Tsourkas
Journal:  Transl Cancer Res       Date:  2013-08-01       Impact factor: 1.241

5.  Theranostic gold nanoparticles modified for durable systemic circulation effectively and safely enhance the radiation therapy of human sarcoma cells and tumors.

Authors:  Daniel Y Joh; Gary D Kao; Surya Murty; Melissa Stangl; Lova Sun; Ajlan Al Zaki; Xiangsheng Xu; Stephen M Hahn; Andrew Tsourkas; Jay F Dorsey
Journal:  Transl Oncol       Date:  2013-12-01       Impact factor: 4.243

6.  Tumor response to radiotherapy regulated by endothelial cell apoptosis.

Authors:  Monica Garcia-Barros; Francois Paris; Carlos Cordon-Cardo; David Lyden; Shahin Rafii; Adriana Haimovitz-Friedman; Zvi Fuks; Richard Kolesnick
Journal:  Science       Date:  2003-05-16       Impact factor: 47.728

7.  Increased apoptotic potential and dose-enhancing effect of gold nanoparticles in combination with single-dose clinical electron beams on tumor-bearing mice.

Authors:  Meng-Ya Chang; Ai-Li Shiau; Yu-Hung Chen; Chih-Jui Chang; Helen H-W Chen; Chao-Liang Wu
Journal:  Cancer Sci       Date:  2008-04-11       Impact factor: 6.716

8.  [General mechanism of intratumor accumulation of macromolecules: advantage of macromolecular therapeutics].

Authors:  Y Matsumura; T Oda; H Maeda
Journal:  Gan To Kagaku Ryoho       Date:  1987-03

Review 9.  Radiotherapy enhancement with gold nanoparticles.

Authors:  James F Hainfeld; F Avraham Dilmanian; Daniel N Slatkin; Henry M Smilowitz
Journal:  J Pharm Pharmacol       Date:  2008-08       Impact factor: 3.765

10.  Gold nanostructures as a platform for combinational therapy in future cancer therapeutics.

Authors:  Salomeh Jelveh; Devika B Chithrani
Journal:  Cancers (Basel)       Date:  2011-03-04       Impact factor: 6.639
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  39 in total

1.  Low Z target switching to increase tumor endothelial cell dose enhancement during gold nanoparticle-aided radiation therapy.

Authors:  Ross I Berbeco; Alexandre Detappe; Panogiotis Tsiamas; David Parsons; Mammo Yewondwossen; James Robar
Journal:  Med Phys       Date:  2016-01       Impact factor: 4.071

2.  Ultrasmall Silica-Based Bismuth Gadolinium Nanoparticles for Dual Magnetic Resonance-Computed Tomography Image Guided Radiation Therapy.

Authors:  Alexandre Detappe; Eloise Thomas; Mark W Tibbitt; Sijumon Kunjachan; Oksana Zavidij; Nishita Parnandi; Elizaveta Reznichenko; François Lux; Olivier Tillement; Ross Berbeco
Journal:  Nano Lett       Date:  2017-02-02       Impact factor: 11.189

3.  Targeted Gold Nanocluster-Enhanced Radiotherapy of Prostate Cancer.

Authors:  Dong Luo; Xinning Wang; Sophia Zeng; Gopalakrishnan Ramamurthy; Clemens Burda; James P Basilion
Journal:  Small       Date:  2019-07-02       Impact factor: 13.281

Review 4.  Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light.

Authors:  Mahdi Karimi; Parham Sahandi Zangabad; Soodeh Baghaee-Ravari; Mehdi Ghazadeh; Hamid Mirshekari; Michael R Hamblin
Journal:  J Am Chem Soc       Date:  2017-03-13       Impact factor: 15.419

Review 5.  Complex interplay between tumor microenvironment and cancer therapy.

Authors:  Minhong Shen; Yibin Kang
Journal:  Front Med       Date:  2018-08-10       Impact factor: 4.592

Review 6.  Stereotactic modulation of blood-brain barrier permeability to enhance drug delivery.

Authors:  Geoff Appelboom; Alexandre Detappe; Melissa LoPresti; Sijumon Kunjachan; Stefan Mitrasinovic; Serge Goldman; Steve D Chang; Olivier Tillement
Journal:  Neuro Oncol       Date:  2016-07-11       Impact factor: 12.300

7.  Increased carcinoembryonic antigen expression on the surface of lung cancer cells using gold nanoparticles during radiotherapy.

Authors:  Romy Mueller; Sayeda Yasmin-Karim; Kaylie DeCosmo; Ana Vazquez-Pagan; Srinivas Sridhar; David Kozono; Juergen Hesser; Wilfred Ngwa
Journal:  Phys Med       Date:  2020-07-27       Impact factor: 2.685

8.  NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis.

Authors:  Christina L Hofmann; Melanie C O'Sullivan; Alexandre Detappe; Yingjie Yu; Xi Yang; Wei Qi; Chelsea D Landon; Michael J Therien; Mark W Dewhirst; P Peter Ghoroghchian; Gregory M Palmer
Journal:  Nanoscale       Date:  2017-09-21       Impact factor: 7.790

9.  Computational Modeling and Clonogenic Assay for Radioenhancement of Gold Nanoparticles Using 3D Live Cell Images.

Authors:  Wonmo Sung; Yoon Jeong; Hyejin Kim; Hoibin Jeong; Clemens Grassberger; Seongmoon Jung; G-One Ahn; Il Han Kim; Jan Schuemann; Kangwon Lee; Sung-Joon Ye
Journal:  Radiat Res       Date:  2018-08-24       Impact factor: 2.841

10.  Edible Ginger-derived Nano-lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach for Colon Cancer Therapy.

Authors:  Mingzhen Zhang; Bo Xiao; Huan Wang; Moon Kwon Han; Zhan Zhang; Emilie Viennois; Changlong Xu; Didier Merlin
Journal:  Mol Ther       Date:  2016-08-05       Impact factor: 11.454
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