Literature DB >> 26418159

Enantioselective Synthesis of Bicyclic δ-Lactones via N-Heterocyclic Carbene-Catalyzed Cascade Reaction.

Zhi-Qin Liang1, Dong-Ling Wang1, Han-Ming Zhang1, Song Ye1.   

Abstract

The N-heterocyclic carbene-catalyzed cascade reaction of enals with malonates to give bicyclic δ-lactones was developed. The cyclopentane- and cyclohexane-fused δ-lactones with three continued stereocenters were obtained in high yields with excellent diastereo- and high enantioselectivities.

Entities:  

Year:  2015        PMID: 26418159     DOI: 10.1021/acs.orglett.5b02695

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

Review 1.  N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes.

Authors:  Xiang-Yu Chen; Sun Li; Fabrizio Vetica; Mukesh Kumar; Dieter Enders
Journal:  iScience       Date:  2018-04-05
  1 in total

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