Literature DB >> 26417860

PRC1 proteins orchestrate three-dimensional genome architecture.

Giacomo Cavalli1.   

Abstract

The three-dimensional organization of the genome has an important role in orchestrating gene expression, but its regulation is poorly understood. Now, a new study uncovers a major role for Polycomb components of the PRC1 complex in organizing physical networks of genes that are co-repressed to maintain pluripotency.

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Year:  2015        PMID： 26417860     DOI： 10.1038/ng.3411

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  14 in total

1.  The pluripotent genome in three dimensions is shaped around pluripotency factors.

Authors:  Elzo de Wit; Britta A M Bouwman; Yun Zhu; Petra Klous; Erik Splinter; Marjon J A M Verstegen; Peter H L Krijger; Nicola Festuccia; Elphège P Nora; Maaike Welling; Edith Heard; Niels Geijsen; Raymond A Poot; Ian Chambers; Wouter de Laat
Journal:  Nature       Date:  2013-07-24       Impact factor: 49.962

2.  SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing.

Authors:  Kyoichi Isono; Takaho A Endo; Manching Ku; Daisuke Yamada; Rie Suzuki; Jafar Sharif; Tomoyuki Ishikura; Tetsuro Toyoda; Bradley E Bernstein; Haruhiko Koseki
Journal:  Dev Cell       Date:  2013-09-30       Impact factor: 12.270

Review 3.  The role of chromosome domains in shaping the functional genome.

Authors:  Tom Sexton; Giacomo Cavalli
Journal:  Cell       Date:  2015-03-12       Impact factor: 41.582

4.  Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain.

Authors:  Maxence Vieux-Rochas; Pierre J Fabre; Marion Leleu; Denis Duboule; Daan Noordermeer
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-30       Impact factor: 11.205

Review 5.  Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put.

Authors:  Jeffrey A Simon; Robert E Kingston
Journal:  Mol Cell       Date:  2013-03-07       Impact factor: 17.970

Review 6.  Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression.

Authors:  Miguel Vidal
Journal:  Int J Dev Biol       Date:  2009       Impact factor: 2.203

7.  Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila.

Authors:  Frédéric Bantignies; Virginie Roure; Itys Comet; Benjamin Leblanc; Bernd Schuettengruber; Jérôme Bonnet; Vanessa Tixier; André Mas; Giacomo Cavalli
Journal:  Cell       Date:  2011-01-21       Impact factor: 41.582

8.  Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome.

Authors:  Stefan Schoenfelder; Robert Sugar; Andrew Dimond; Biola-Maria Javierre; Harry Armstrong; Borbala Mifsud; Emilia Dimitrova; Louise Matheson; Filipe Tavares-Cadete; Mayra Furlan-Magaril; Anne Segonds-Pichon; Wiktor Jurkowski; Steven W Wingett; Kristina Tabbada; Simon Andrews; Bram Herman; Emily LeProust; Cameron S Osborne; Haruhiko Koseki; Peter Fraser; Nicholas M Luscombe; Sarah Elderkin
Journal:  Nat Genet       Date:  2015-08-31       Impact factor: 38.330

Review 9.  The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states.

Authors:  Nicola Festuccia; Rodrigo Osorno; Valerie Wilson; Ian Chambers
Journal:  Curr Opin Genet Dev       Date:  2013-08-07       Impact factor: 5.578

10.  Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization.

Authors:  Stefanie Rosa; Filomena De Lucia; Joshua S Mylne; Danling Zhu; Nobuko Ohmido; Ali Pendle; Naohiro Kato; Peter Shaw; Caroline Dean
Journal:  Genes Dev       Date:  2013-09-01       Impact factor: 11.361
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