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Literature DB >> 26417859

Adeno-associated virus finds its disease.

Abstract

Adeno-associated virus (AAV) vectors have been widely adopted for use in gene therapy. A new study raises concerns regarding this approach, reporting that chromosomal insertions of AAV serotype 2 seem to activate proto-oncogenes in human hepatocellular carcinoma.

Entities: Disease Gene Species

Mesh：

Year: 2015 PMID： 26417859 PMCID： PMC4762592 DOI： 10.1038/ng.3407

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

14 in total

1. Induction of hepatocellular carcinoma by in vivo gene targeting.

Authors: Pei-Rong Wang; Mei Xu; Sara Toffanin; Yi Li; Josep M Llovet; David W Russell
Journal: Proc Natl Acad Sci U S A Date: 2012-06-25 Impact factor: 11.205

2. Emerging trends in hepatocellular carcinoma incidence and mortality.

Authors: Basile Njei; Yaron Rotman; Ivo Ditah; Joseph K Lim
Journal: Hepatology Date: 2014-11-24 Impact factor: 17.425

3. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma.

Authors: Wing-Kin Sung; Hancheng Zheng; Shuyu Li; Ronghua Chen; Xiao Liu; Yingrui Li; Nikki P Lee; Wah H Lee; Pramila N Ariyaratne; Chandana Tennakoon; Fabianus H Mulawadi; Kwong F Wong; Angela M Liu; Ronnie T Poon; Sheung Tat Fan; Kwong L Chan; Zhuolin Gong; Yujie Hu; Zhao Lin; Guan Wang; Qinghui Zhang; Thomas D Barber; Wen-Chi Chou; Amit Aggarwal; Ke Hao; Wei Zhou; Chunsheng Zhang; James Hardwick; Carolyn Buser; Jiangchun Xu; Zhengyan Kan; Hongyue Dai; Mao Mao; Christoph Reinhard; Jun Wang; John M Luk
Journal: Nat Genet Date: 2012-05-27 Impact factor: 38.330

Review 4. Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development.

Authors: Chun-Meng Jiang; Chun-Wen Pu; Ya-Hui Hou; Zhe Chen; Mohammed Alanazy; Lionel Hebbard
Journal: World J Gastroenterol Date: 2014-11-28 Impact factor: 5.742

5. Adeno-associated virus vectors preferentially transduce cells in S phase.

Authors: D W Russell; A D Miller; I E Alexander
Journal: Proc Natl Acad Sci U S A Date: 1994-09-13 Impact factor: 11.205

6. AAV vector integration sites in mouse hepatocellular carcinoma.

Authors: Anthony Donsante; Daniel G Miller; Yi Li; Carole Vogler; Elizabeth M Brunt; David W Russell; Mark S Sands
Journal: Science Date: 2007-07-27 Impact factor: 47.728

7. Adeno-associated virus biology.

Authors: Matthew D Weitzman; R Michael Linden
Journal: Methods Mol Biol Date: 2011

8. Promoterless gene targeting without nucleases ameliorates haemophilia B in mice.

Authors: A Barzel; N K Paulk; Y Shi; Y Huang; K Chu; F Zhang; P N Valdmanis; L P Spector; M H Porteus; K M Gaensler; M A Kay
Journal: Nature Date: 2014-10-29 Impact factor: 49.962

9. Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis.

Authors: Jesse D Riordan; Vincent W Keng; Barbara R Tschida; Todd E Scheetz; Jason B Bell; Kelly M Podetz-Pedersen; Catherine D Moser; Neal G Copeland; Nancy A Jenkins; Lewis R Roberts; David A Largaespada; Adam J Dupuy
Journal: PLoS Genet Date: 2013-04-04 Impact factor: 5.917

10. Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer.

Authors: Marco Ranzani; Daniela Cesana; Cynthia C Bartholomae; Francesca Sanvito; Mauro Pala; Fabrizio Benedicenti; Pierangela Gallina; Lucia Sergi Sergi; Stefania Merella; Alessandro Bulfone; Claudio Doglioni; Christof von Kalle; Yoon Jun Kim; Manfred Schmidt; Giovanni Tonon; Luigi Naldini; Eugenio Montini
Journal: Nat Methods Date: 2013-01-13 Impact factor: 28.547

19 in total

Review 1. Improving Molecular Therapy in the Kidney.

Authors: Jeffrey D Rubin; Michael A Barry
Journal: Mol Diagn Ther Date: 2020-08 Impact factor: 4.074

2. Genotoxicity in Mice Following AAV Gene Delivery: A Safety Concern for Human Gene Therapy?

Authors: Randy J Chandler; Matthew C LaFave; Gaurav K Varshney; Shawn M Burgess; Charles P Venditti
Journal: Mol Ther Date: 2016-02 Impact factor: 11.454

3. Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

Authors: Grant J Logan; Allison P Dane; Claus V Hallwirth; Christine M Smyth; Emilie E Wilkie; Anais K Amaya; Erhua Zhu; Neeta Khandekar; Samantha L Ginn; Sophia H Y Liao; Sharon C Cunningham; Natsuki Sasaki; Martí Cabanes-Creus; Patrick P L Tam; David W Russell; Leszek Lisowski; Ian E Alexander
Journal: Nat Genet Date: 2017-06-19 Impact factor: 38.330

Review 4. Messenger RNA Delivery for Tissue Engineering and Regenerative Medicine Applications.

Authors: Siddharth Patel; Avathamsa Athirasala; Paula P Menezes; N Ashwanikumar; Ting Zou; Gaurav Sahay; Luiz E Bertassoni
Journal: Tissue Eng Part A Date: 2018-06-07 Impact factor: 3.845

5. Comparison of Gene Delivery to the Kidney by Adenovirus, Adeno-Associated Virus, and Lentiviral Vectors After Intravenous and Direct Kidney Injections.

Authors: Jeffrey D Rubin; Tien V Nguyen; Kari L Allen; Katayoun Ayasoufi; Michael A Barry
Journal: Hum Gene Ther Date: 2019-12-03 Impact factor: 5.695

Review 10. Genetic basis of hepatitis virus-associated hepatocellular carcinoma: linkage between infection, inflammation, and tumorigenesis.

Authors: Haruhiko Takeda; Atsushi Takai; Tadashi Inuzuka; Hiroyuki Marusawa
Journal: J Gastroenterol Date: 2016-10-06 Impact factor: 7.527