Yoshikane Yamauchi1, Thomas Muley2, Seyer Safi1, Stefan Rieken3, Helge Bischoff4, Jutta Kappes5, Arne Warth6, Felix J F Herth7, Hendrik Dienemann1, Hans Hoffmann8. 1. Department of Thoracic Surgery, Thoraxklinik, Heidelberg University, Heidelberg, Germany. 2. Translational Research Unit, Thoraxklinik, Heidelberg University, Heidelberg, Germany; Translational Lung Research Center Heidelberg, Heidelberg, Germany. 3. Department of Radiation Oncology, Heidelberg University, Heidelberg, Germany. 4. Department of Thoracic Oncology/Internal Medicine, Thoraxklinik, Heidelberg University, Heidelberg, Germany. 5. Pneumology and Critical Care Medicine, Thoraxklinik, Heidelberg University, Heidelberg, Germany. 6. Institute of Pathology, Heidelberg University, Heidelberg, Germany; Translational Lung Research Center Heidelberg, Heidelberg, Germany. 7. Pneumology and Critical Care Medicine, Thoraxklinik, Heidelberg University, Heidelberg, Germany; Translational Lung Research Center Heidelberg, Heidelberg, Germany. 8. Department of Thoracic Surgery, Thoraxklinik, Heidelberg University, Heidelberg, Germany. Electronic address: hans.hoffmann@urz.uni-heidelberg.de.
Abstract
PURPOSE: To investigate the hazard function of tumor recurrence in patients with completely (R0) resected non-small cell lung cancer. METHODS: A total of 1374 patients treated between 2003 and 2009 with complete resection and systematic lymph node dissection were studied. The risk of recurrence at a given time after operation was studied utilizing the cause-specific hazard function. Recurrence was categorized as local recurrence or distant recurrence. The risk distribution was assessed using clinical and pathological factors. RESULTS: The hazard function for recurrence presented an early peak at approximately 10 months after surgery and maintained a tapered plateau-like tail extending up to 8 years. A similar risk pattern was detected for both local recurrence and distant recurrence, while the risk of distant recurrence was higher than that of local recurrence. The double-peaked pattern of hazard rate was present in several subgroups, such as p-stage IA patients. A comparison of histology and status of nodal involvement showed that pN1-2 adenocarcinoma patients demonstrated a high hazard rate of distant recurrence and that pN0 adenocarcinoma patients exhibited a small recurrent risk for a longer time. Squamous cell carcinoma patients showed only little difference in risk. CONCLUSIONS: The data may be useful to select patients at high risk of recurrence and may provide information for each patient to decide how to manage the postoperative follow-up individually.
PURPOSE: To investigate the hazard function of tumor recurrence in patients with completely (R0) resected non-small cell lung cancer. METHODS: A total of 1374 patients treated between 2003 and 2009 with complete resection and systematic lymph node dissection were studied. The risk of recurrence at a given time after operation was studied utilizing the cause-specific hazard function. Recurrence was categorized as local recurrence or distant recurrence. The risk distribution was assessed using clinical and pathological factors. RESULTS: The hazard function for recurrence presented an early peak at approximately 10 months after surgery and maintained a tapered plateau-like tail extending up to 8 years. A similar risk pattern was detected for both local recurrence and distant recurrence, while the risk of distant recurrence was higher than that of local recurrence. The double-peaked pattern of hazard rate was present in several subgroups, such as p-stage IApatients. A comparison of histology and status of nodal involvement showed that pN1-2 adenocarcinomapatients demonstrated a high hazard rate of distant recurrence and that pN0 adenocarcinomapatients exhibited a small recurrent risk for a longer time. Squamous cell carcinomapatients showed only little difference in risk. CONCLUSIONS: The data may be useful to select patients at high risk of recurrence and may provide information for each patient to decide how to manage the postoperative follow-up individually.
Authors: Yusuke Takahashi; Takashi Eguchi; Koji Kameda; Shaohua Lu; Raj G Vaghjiani; Kay See Tan; William D Travis; David R Jones; Prasad S Adusumilli Journal: Oncotarget Date: 2018-11-06
Authors: Helen Pasternack; Christiane Kuempers; Mario Deng; Iris Watermann; Till Olchers; Mark Kuehnel; Danny Jonigk; Christian Kugler; Florian Stellmacher; Torsten Goldmann; Jutta Kirfel; Ole Ammerpohl; Sven Perner; Martin Reck Journal: Sci Rep Date: 2021-05-05 Impact factor: 4.379