Erin M Marra1, Maryann Mazer-Amirshahi2, Gillian Brooks3, John van den Anker4,5,6,7, Larissa May8, Jesse M Pines8. 1. Department of Emergency Medicine, Long Island Jewish Medical Center, New Hyde Park, New York. 2. Department of Emergency Medicine, MedStar Washington Hospital Center, Washington, District of Columbia. 3. School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia. 4. Department of Pediatrics, George Washington University, Washington, District of Columbia. 5. Department of Clinical Pharmacology, Children's National Medical Center, Washington, District of Columbia. 6. Intensive Care, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, the Netherlands. 7. Department of Paediatric Pharmacology, University Children's Hospital Basel, Basel, Switzerland. 8. Department of Emergency Medicine, George Washington University, Washington, District of Columbia.
Abstract
OBJECTIVES: To assess trends in benzodiazepine use from 2001 to 2010 in older adults in U.S. ambulatory clinics and emergency departments (EDs). DESIGN: Retrospective analysis. SETTING: 2001 to 2010 National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS). PARTICIPANTS: Individuals aged 65 and older for whom the reason for visit might prompt a physician to use a benzodiazepine (e.g., anxiety, detoxification, back sprain). MEASUREMENTS: The NAMCS and NHAMCS were used to evaluate U.S. ambulatory clinic and ED visits. Encounters involving individuals aged 65 and older for whom a benzodiazepine might be prescribed were analyzed. Trends in benzodiazepine use in these visits were explored, and predictors of use were assessed using survey-weighted chi-square tests and logistic regression. RESULTS: From 2001 to 2010, benzodiazepines were used in 16.6 million of 133.3 million ambulatory clinic visits and 1.9 million of 18.1 million ED visits with the selected reasons for the visits. There was no change in benzodiazepine use in either setting over the study period, although benzodiazepine use for those aged 85 and older increased from 8.9% to 19.3% in ambulatory clinics and 10.1% to 17.2% in EDs. Individuals visiting clinics with anxiety were five times as likely to receive benzodiazepines (odds ratio (OR) = 4.8), and those in EDs were twice as likely (OR = 2.3). CONCLUSION: Despite safety concerns, benzodiazepine use in older adults in U.S. ambulatory clinics and EDs did not change from 2001 to 2010. In the oldest individuals, who are at higher risk of adverse events, a greater increase was seen than in those aged 65 to 84. Additional measures may be needed to promote alternatives to benzodiazepines.
OBJECTIVES: To assess trends in benzodiazepine use from 2001 to 2010 in older adults in U.S. ambulatory clinics and emergency departments (EDs). DESIGN: Retrospective analysis. SETTING: 2001 to 2010 National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS). PARTICIPANTS: Individuals aged 65 and older for whom the reason for visit might prompt a physician to use a benzodiazepine (e.g., anxiety, detoxification, back sprain). MEASUREMENTS: The NAMCS and NHAMCS were used to evaluate U.S. ambulatory clinic and ED visits. Encounters involving individuals aged 65 and older for whom a benzodiazepine might be prescribed were analyzed. Trends in benzodiazepine use in these visits were explored, and predictors of use were assessed using survey-weighted chi-square tests and logistic regression. RESULTS: From 2001 to 2010, benzodiazepines were used in 16.6 million of 133.3 million ambulatory clinic visits and 1.9 million of 18.1 million ED visits with the selected reasons for the visits. There was no change in benzodiazepine use in either setting over the study period, although benzodiazepine use for those aged 85 and older increased from 8.9% to 19.3% in ambulatory clinics and 10.1% to 17.2% in EDs. Individuals visiting clinics with anxiety were five times as likely to receive benzodiazepines (odds ratio (OR) = 4.8), and those in EDs were twice as likely (OR = 2.3). CONCLUSION: Despite safety concerns, benzodiazepine use in older adults in U.S. ambulatory clinics and EDs did not change from 2001 to 2010. In the oldest individuals, who are at higher risk of adverse events, a greater increase was seen than in those aged 65 to 84. Additional measures may be needed to promote alternatives to benzodiazepines.
Authors: Mitchell Kim; Stephen J Kaplan; Steven H Mitchell; Medley Gatewood; Itay Bentov; Katherine A Bennett; Carol A Crawford; Paul R Sutton; Diane Matsuwaka; Mamatha Damodarasamy; May J Reed Journal: Drugs Aging Date: 2017-10 Impact factor: 3.923
Authors: Donovan T Maust; Frederic C Blow; Ilse R Wiechers; Helen C Kales; Steven C Marcus Journal: J Clin Psychiatry Date: 2017-04 Impact factor: 4.384
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Authors: Mitchell Kim; Steven H Mitchell; Medley Gatewood; Katherine A Bennett; Paul R Sutton; Carol A Crawford; Itay Bentov; Mamatha Damodarasamy; Stephen J Kaplan; May J Reed Journal: Drug Healthc Patient Saf Date: 2017-11-08