| Literature DB >> 26415 |
F Toma, S Fermandjian, M Löw, L Kisfaludy.
Abstract
250 MHz 1H-NMR studies performed on aqueous solutions of corticotropin1-32, corticotropin1-24, corticotropin15-32, corticotropin20-32 and corticotropin15-24 have allowed the location and the subsequent assignment of the signals of Tyrosine-23 aromatic protons and valine-22 methyl protons. These signals are sensitive to the geometry of proline-24, clearly transcribe its isomerism and yield the ratio of the cis-trans conformers. It is concluded that for large peptides in specific cases, the proton signals of side chains can be used to probe the backbone conformation.Entities:
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Year: 1978 PMID： 26415 DOI： 10.1016/0005-2795(78)90481-6
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002