Literature DB >> 26414883

A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment.

Wonhwa Lee1,2, Junyoung Seo2, Soyoung Kwak1, Eun Ji Park1, Dong Hee Na1, Soyoun Kim2, You Mie Lee1, In-San Kim3,4, Jong-Sup Bae1,2.   

Abstract

New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  PC-gla; TRAP; ferritin; nanoparticles; sepsis

Mesh：

Substances：

Year:  2015        PMID： 26414883     DOI： 10.1002/adma.201503093

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  9 in total

1.  Multistage targeting and dual inhibiting strategies based on bioengineered tumor matrix microenvironment-mediated protein nanocages for enhancing cancer biotherapy.

Authors:  Fabiao Hu; Changping Deng; Yiwen Zhou; Yuping Liu; Tong Zhang; Peiwen Zhang; Zhangting Zhao; Hui Miao; Wenyun Zheng; Wenliang Zhang; Meiyan Wang; Xingyuan Ma
Journal:  Bioeng Transl Med       Date:  2022-01-05

Review 2.  Nanoplatforms for Sepsis Management: Rapid Detection/Warning, Pathogen Elimination and Restoring Immune Homeostasis.

Authors:  Gan Luo; Jue Zhang; Yaqi Sun; Ya Wang; Hanbin Wang; Baoli Cheng; Qiang Shu; Xiangming Fang
Journal:  Nanomicro Lett       Date:  2021-03-08

3.  Inhibition of platelet aggregation and thrombosis by indole alkaloids isolated from the edible insect Protaetia brevitarsis seulensis (Kolbe).

Authors:  JungIn Lee; Wonhwa Lee; Mi-Ae Kim; Jae Sam Hwang; MinKyun Na; Jong-Sup Bae
Journal:  J Cell Mol Med       Date:  2016-12-20       Impact factor: 5.310

4.  Antithrombotic properties of JJ1, a potent and novel thrombin inhibitor.

Authors:  Wonhwa Lee; Suyeon Lee; Joonhyeok Choi; Jun-Hyeong Park; Kyung-Min Kim; Jun-Goo Jee; Jong-Sup Bae
Journal:  Sci Rep       Date:  2017-11-01       Impact factor: 4.379

5.  Two Gene Set Variation Index as Biomarker of Bacterial and Fungal Sepsis.

Authors:  Xiaowen Zheng; Yifeng Luo; Qian Li; Jihua Feng; Chunling Zhao; Junyu Lu; Jiefeng Luo; Jianfeng Zhang
Journal:  Biomed Res Int       Date:  2020-06-03       Impact factor: 3.411

6.  Synergistic effect of GF9 and streptomycin on relieving gram-negative bacteria-induced sepsis.

Authors:  Bing Wei; Yingmin Ma
Journal:  Front Bioeng Biotechnol       Date:  2022-08-30

7.  Cleavage-Responsive Biofactory T Cells Suppress Infectious Diseases-Associated Hypercytokinemia.

Authors:  Hyelim Kim; Boram Son; Eun U Seo; Miji Kwon; June Hong Ahn; Heungsoo Shin; Gyu Yong Song; Eun Ji Park; Dong Hee Na; Seung-Woo Cho; Hong Nam Kim; Hee Ho Park; Wonhwa Lee
Journal:  Adv Sci (Weinh)       Date:  2022-06-25       Impact factor: 17.521

Review 8.  Ferritin - a multifaceted protein scaffold for biotherapeutics.

Authors:  Na Kyeong Lee; Seongeon Cho; In-San Kim
Journal:  Exp Mol Med       Date:  2022-10-03       Impact factor: 12.153

9.  Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities.

Authors:  Young Sun Choi; Hyeonha Jang; Biki Gupta; Ji-Hak Jeong; Yun Ge; Chul Soon Yong; Jong Oh Kim; Jong-Sup Bae; Im-Sook Song; In-San Kim; You Mie Lee
Journal:  J Hematol Oncol       Date:  2020-09-14       Impact factor: 17.388
  9 in total

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