Literature DB >> 26414764

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants.

Veronica De Rosa1,2, Mario Galgani1, Antonio Porcellini3, Alessandra Colamatteo2,4, Marianna Santopaolo5, Candida Zuchegna3, Antonella Romano3, Salvatore De Simone1, Claudio Procaccini1, Claudia La Rocca1, Pietro Biagio Carrieri6, Giorgia Teresa Maniscalco7, Marco Salvetti8, Maria Chiara Buscarinu8, Adriana Franzese9, Enza Mozzillo9, Antonio La Cava10, Giuseppe Matarese4,11.   

Abstract

Human regulatory T cells (T(reg) cells) that develop from conventional T cells (T(conv) cells) following suboptimal stimulation via the T cell antigen receptor (TCR) (induced T(reg) cells (iT(reg) cells)) express the transcription factor Foxp3, are suppressive, and display an active proliferative and metabolic state. Here we found that the induction and suppressive function of iT(reg) cells tightly depended on glycolysis, which controlled Foxp3 splicing variants containing exon 2 (Foxp3-E2) through the glycolytic enzyme enolase-1. The Foxp3-E2-related suppressive activity of iT(reg) cells was altered in human autoimmune diseases, including multiple sclerosis and type 1 diabetes, and was associated with impaired glycolysis and signaling via interleukin 2. This link between glycolysis and Foxp3-E2 variants via enolase-1 shows a previously unknown mechanism for controlling the induction and function of T(reg) cells in health and in autoimmunity.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26414764      PMCID： PMC4868085          DOI： 10.1038/ni.3269

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  46 in total

1.  Regulatory T cell development in the absence of functional Foxp3.

Authors:  Wen Lin; Dipica Haribhai; Lance M Relland; Nga Truong; Marc R Carlson; Calvin B Williams; Talal A Chatila
Journal:  Nat Immunol       Date:  2007-02-02       Impact factor: 25.606

2.  Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.

Authors:  Valerie A Gerriets; Rigel J Kishton; Amanda G Nichols; Andrew N Macintyre; Makoto Inoue; Olga Ilkayeva; Peter S Winter; Xiaojing Liu; Bhavana Priyadharshini; Marta E Slawinska; Lea Haeberli; Catherine Huck; Laurence A Turka; Kris C Wood; Laura P Hale; Paul A Smith; Martin A Schneider; Nancie J MacIver; Jason W Locasale; Christopher B Newgard; Mari L Shinohara; Jeffrey C Rathmell
Journal:  J Clin Invest       Date:  2014-12-01       Impact factor: 14.808

3.  Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.

Authors:  Mindi R Walker; Deborah J Kasprowicz; Vivian H Gersuk; Angele Benard; Megan Van Landeghen; Jane H Buckner; Steven F Ziegler
Journal:  J Clin Invest       Date:  2003-11       Impact factor: 14.808

4.  TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo.

Authors:  Rachel A Gottschalk; Emily Corse; James P Allison
Journal:  J Exp Med       Date:  2010-07-26       Impact factor: 14.307

5.  Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion.

Authors:  Michael S Turner; Lawrence P Kane; Penelope A Morel
Journal:  J Immunol       Date:  2009-10-15       Impact factor: 5.422

6.  The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

Authors:  Sarah E Allan; Laura Passerini; Rosa Bacchetta; Natasha Crellin; Minyue Dai; Paul C Orban; Steven F Ziegler; Maria Grazia Roncarolo; Megan K Levings
Journal:  J Clin Invest       Date:  2005-10-06       Impact factor: 14.808

7.  Role of cytokines in thymus- versus peripherally derived-regulatory T cell differentiation and function.

Authors:  Jérémie David Goldstein; Louis Pérol; Bruno Zaragoza; Audrey Baeyens; Gilles Marodon; Eliane Piaggio
Journal:  Front Immunol       Date:  2013-06-19       Impact factor: 7.561

8.  TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.

Authors:  Liang Zhou; Jared E Lopes; Mark M W Chong; Ivaylo I Ivanov; Roy Min; Gabriel D Victora; Yuelei Shen; Jianguang Du; Yuri P Rubtsov; Alexander Y Rudensky; Steven F Ziegler; Dan R Littman
Journal:  Nature       Date:  2008-03-26       Impact factor: 49.962

9.  Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.

Authors:  WanJun Chen; Wenwen Jin; Neil Hardegen; Ke-Jian Lei; Li Li; Nancy Marinos; George McGrady; Sharon M Wahl
Journal:  J Exp Med       Date:  2003-12-15       Impact factor: 14.307

10.  DNA damage, homology-directed repair, and DNA methylation.

Authors:  Concetta Cuozzo; Antonio Porcellini; Tiziana Angrisano; Annalisa Morano; Bongyong Lee; Alba Di Pardo; Samantha Messina; Rodolfo Iuliano; Alfredo Fusco; Maria R Santillo; Mark T Muller; Lorenzo Chiariotti; Max E Gottesman; Enrico V Avvedimento
Journal:  PLoS Genet       Date:  2007-07       Impact factor: 5.917
View more
  162 in total

1.  Immunometabolic biomarkers of inflammation in Behçet's disease: relationship with epidemiological profile, disease activity and therapeutic regimens.

Authors:  L Cantarini; V Pucino; A Vitale; R Talarico; O M Lucherini; F Magnotti; V De Rosa; M Galgani; C Alviggi; G Marone; M Galeazzi; G Matarese
Journal:  Clin Exp Immunol       Date:  2016-02-24       Impact factor: 4.330

Review 2.  A guide to immunometabolism for immunologists.

Authors:  Luke A J O'Neill; Rigel J Kishton; Jeff Rathmell
Journal:  Nat Rev Immunol       Date:  2016-07-11       Impact factor: 53.106

Review 3.  Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology.

Authors:  Daniel F J Ketelhuth; Esther Lutgens; Magnus Bäck; Christoph J Binder; Jan Van den Bossche; Carolin Daniel; Ingrid E Dumitriu; Imo Hoefer; Peter Libby; Luke O'Neill; Christian Weber; Paul C Evans
Journal:  Cardiovasc Res       Date:  2019-07-01       Impact factor: 10.787

Review 4.  Role of Metabolism in the Immunobiology of Regulatory T Cells.

Authors:  Mario Galgani; Veronica De Rosa; Antonio La Cava; Giuseppe Matarese
Journal:  J Immunol       Date:  2016-10-01       Impact factor: 5.422

5.  mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells.

Authors:  Im-Hong Sun; Min-Hee Oh; Liang Zhao; Chirag H Patel; Matthew L Arwood; Wei Xu; Ada J Tam; Richard L Blosser; Jiayu Wen; Jonathan D Powell
Journal:  J Immunol       Date:  2018-06-08       Impact factor: 5.422

6.  Cutting Edge: Increased Autoimmunity Risk in Glycogen Storage Disease Type 1b Is Associated with a Reduced Engagement of Glycolysis in T Cells and an Impaired Regulatory T Cell Function.

Authors:  Daniela Melis; Fortunata Carbone; Giorgia Minopoli; Claudia La Rocca; Francesco Perna; Veronica De Rosa; Mario Galgani; Generoso Andria; Giancarlo Parenti; Giuseppe Matarese
Journal:  J Immunol       Date:  2017-04-07       Impact factor: 5.422

7.  Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control.

Authors:  Annelise Y Mah; Armin Rashidi; Molly P Keppel; Nermina Saucier; Emily K Moore; Joshua B Alinger; Sandeep K Tripathy; Sandeep K Agarwal; Emily K Jeng; Hing C Wong; Jeffrey S Miller; Todd A Fehniger; Emily M Mace; Anthony R French; Megan A Cooper
Journal:  JCI Insight       Date:  2017-12-07

Review 8.  Differential T-cell receptor signals for T helper cell programming.

Authors:  Penelope A Morel
Journal:  Immunology       Date:  2018-05-25       Impact factor: 7.397

Review 9.  Regulatory T Cells: Central Concepts from Ontogeny to Therapy.

Authors:  Bernard Khor
Journal:  Transfus Med Rev       Date:  2016-07-26

Review 10.  Immunometabolism of regulatory T cells.

Authors:  Ryan Newton; Bhavana Priyadharshini; Laurence A Turka
Journal:  Nat Immunol       Date:  2016-05-19       Impact factor: 25.606
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.